5104-49-4
5104-49-4 structure
- Name: Flurbiprofen
- Chemical Name: flurbiprofen
- CAS Number: 5104-49-4
- Molecular Formula: C15H13FO2
- Molecular Weight: 244.261
- Catalog: API Antipyretic analgesics Non-steroidal anti-inflammatory drugs
- Create Date: 2018-09-18 10:00:47
- Modify Date: 2024-01-02 16:48:39
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Flurbiprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity.Target: PGE synthaseFlurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically prior to ocular surgery to prevent or reduce intraoperative miosis. Flurbiprofen is structurally and pharmacologically related to fenoprofen, ibuprofen, and ketoprofen. Flurbiprofen may have unique pharmacological properties that reduce the accumulation of unfolded proteins and may represent a new class of drug for the fundamental treatment of obesity [1]. Flurbiprofen and its enantiomers selectively lower Aβ42 levels in broken cell γ-secretase assays, indicating that these compounds directly target the γ-secretase complex that generates Aβ from APP. Of the compounds tested, meclofenamic acid, racemic flurbiprofen, and the purified R and S enantiomers of flurbiprofen lowered Aβ42 levels to the greatest extent [2].
| Name | flurbiprofen |
|---|---|
| Synonyms |
froben
R-Flurbiprofen R-(-)-Flurbiprofen (2R)-2-(2-fluorobiphenyl-4-yl)propanoic acid 2-(2-Fluorobiphenyl-4-yl)propionic Acid (-)-Flurbiprofen (R)-Flurbiprofen ANSAID EINECS 225-827-6 (2R)-2-(2-Fluoro-1,1'-biphenyl-4-yl)propanoic acid Cebutid Stayban fp70 (R)-2-Flubiprofen MFCD00079303 ANSIDE (R)-(−)-2-Fluoro-α-methyl-4-biphenylacetic acid (2R)-2-(2-Fluoro-4-biphenylyl)propanoic acid (R)-2-Flurbiprofen [1,1'-Biphenyl]-4-acetic acid, 2-fluoro-α-methyl-, (αR)- Zepolas Adfeed Antadys Flurbiprofen |
| Description | Flurbiprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity.Target: PGE synthaseFlurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically prior to ocular surgery to prevent or reduce intraoperative miosis. Flurbiprofen is structurally and pharmacologically related to fenoprofen, ibuprofen, and ketoprofen. Flurbiprofen may have unique pharmacological properties that reduce the accumulation of unfolded proteins and may represent a new class of drug for the fundamental treatment of obesity [1]. Flurbiprofen and its enantiomers selectively lower Aβ42 levels in broken cell γ-secretase assays, indicating that these compounds directly target the γ-secretase complex that generates Aβ from APP. Of the compounds tested, meclofenamic acid, racemic flurbiprofen, and the purified R and S enantiomers of flurbiprofen lowered Aβ42 levels to the greatest extent [2]. |
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| Related Catalog | |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 376.2±30.0 °C at 760 mmHg |
| Melting Point | 110-112 °C(lit.) |
| Molecular Formula | C15H13FO2 |
| Molecular Weight | 244.261 |
| Flash Point | 181.3±24.6 °C |
| Exact Mass | 244.089951 |
| PSA | 37.30000 |
| LogP | 4.11 |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
| Index of Refraction | 1.568 |
| Storage condition | Store at RT |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 |
| Precautionary Statements | Missing Phrase - N15.00950417 |
| Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
| Hazard Codes | T,C |
| Risk Phrases | R25 |
| Safety Phrases | S36/37/39-S45 |
| RIDADR | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | DU8341000 |
| Packaging Group | III |
| Hazard Class | 6.1(b) |
| HS Code | 2916399090 |
| Precursor 9 | |
|---|---|
| DownStream 3 | |
![methyl 2-[4-(4-acetylphenyl)-3-fluorophenyl]propanoate structure](https://image.chemsrc.com/caspic/478/215175-83-0.png)
| HS Code | 2916399090 |
|---|---|
| Summary | 2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |