Top Suppliers:I want be here
  • BioBioPha
  • China
  • Product Name: Cyclovirobuxine
  • Price: ￥Inquiry/5mg
  • Purity: 98.0%
  • Stocking Period: 10 Day
  • Contact: Xueping-Zheng
Related CAS#:
860-79-7 30276-35-8
808-94-6 1158522-08-7
2402776-80-9 940364-43-2
134104-43-1 131615-57-1
6906-52-1 930439-75-1
1018584-77-4 1375289-11-4
849349-65-1

860-79-7

860-79-7 structure
860-79-7 structure
  • Name: Cyclovirobuxine
  • Chemical Name: Cyclovirobuxin D
  • CAS Number: 860-79-7
  • Molecular Formula: C26H46N2O
  • Molecular Weight: 402.656
  • Catalog: API Circulatory system medication Prevention and treatment of angina pectoris
  • Create Date: 2018-09-29 10:36:31
  • Modify Date: 2024-01-03 18:12:19
  • Cyclovirobuxine D (CVB-D) is the main active component of the traditional Chinese medicine Buxus microphylla. Cyclovirobuxine D induces autophagy and attenuates the phosphorylation of Akt and mTOR[1]. Cyclovirobuxine D inhibits cell proliferation of gastric cancer cells through suppression of cell cycle progression and inducement of mitochondria-mediated apoptosis[2]. Cyclovirobuxine D is beneficial for heart failure induced by myocardial infarction[3].
Name Cyclovirobuxin D
Synonyms MFCD00468040
9,19-Cyclopregnan-16-ol, 4,4,14-trimethyl-3,20-bis(methylamino)-, (3β,5α,9β,16α,20S)-
bebuxine
cyclovirobuxind
cyclovirobuxinum D
cyclobuxine D
(3β,5α,9β,16α,20S)-4,4,14-Trimethyl-3,20-bis(methylamino)-9,19-cyclopregnan-16-ol
cvb-d
Cyclovirobuxine-D
CYCLOVIROBUXINE
Description Cyclovirobuxine D (CVB-D) is the main active component of the traditional Chinese medicine Buxus microphylla. Cyclovirobuxine D induces autophagy and attenuates the phosphorylation of Akt and mTOR[1]. Cyclovirobuxine D inhibits cell proliferation of gastric cancer cells through suppression of cell cycle progression and inducement of mitochondria-mediated apoptosis[2]. Cyclovirobuxine D is beneficial for heart failure induced by myocardial infarction[3].
Related Catalog
In Vitro Cyclovirobuxine D (0-240 µM ;24-72 hours) shows a concentration- and time-dependent reduced cell viability after CVB-D treatment, only 10% MGC-803 cells and 20% MKN28 cells are alive at 72 h after treatment with 240 µM[2]. Cyclovirobuxine D (0-120 µM; 48 hours) arrests the cell cycle of gastric cancer cells at S phase in a concentration-dependent manner[2]. Cyclovirobuxine D (0-120 µM; 48 hours) leads to apoptosis in gastric cancer cells in a concentration-dependent manner, especially early stage apoptosis.Cyclovirobuxine D (0-120 µM; 48 hours) causes apoptosis via up-regulation of the apoptosis- related proteins, cleaved Caspase-3 and ratio of Bax/Bcl-2, in gastric cancer cells[2]. Cell Viability Assay[2] Cell Line: MGC-803 and MKN28 cells Concentration: 0, 30, 60, 120 and 240 µM Incubation Time: 24, 48, 72 hours Result: Reduced Cell Viability and Colony Formation Ability of Gastric Cancer Cells Cell Cycle Analysis[2] Cell Line: MGC-803 and MKN28 cells Concentration: 0, 30, 60, and 120 µM Incubation Time: 48 hours Result: Arrested cell cycle progressions of MGC-803 and MKN28 cells. Apoptosis Analysis[2] Cell Line: MGC-803 and MKN28 cells Concentration: 0, 30, 60, and 120 µM Incubation Time: 48 hours Result: Induced apoptosis of MGC-803 and MKN28 cells. Western Blot Analysis[2] Cell Line: MGC-803 and MKN28 cells Concentration: 0, 30, 60, and 120 µM Incubation Time: 48 hours Result: Up-regulated cleaved Caspase-3 and Bax and decreased the expression of Bcl-2 expression.
References

[1]. Lu J, et al. Cyclovirobuxine D induces autophagy-associated cell death via the Akt/mTOR pathway in MCF-7 human breast cancer cells. J Pharmacol Sci. 2014;125(1):74-82. Epub 2014 Apr 24.

[2]. Wu J, et al. Cyclovirobuxine D Inhibits Cell Proliferation and Induces Mitochondria-Mediated Apoptosis in Human Gastric Cancer Cells. Molecules. 2015 Nov 19;20(11):20659-68.

[3]. Yu B, et al. Beneficial effect of Cyclovirobuxine D on heart failure rats following myocardial infarction. Fitoterapia. 2011 Sep;82(6):868-77.
Density 1.1±0.1 g/cm3
Boiling Point 495.7±10.0 °C at 760 mmHg
Molecular Formula C26H46N2O
Molecular Weight 402.656
Flash Point 34.1±9.6 °C
Exact Mass 402.361023
PSA 44.29000
LogP 4.86
Vapour Pressure 0.0±2.9 mmHg at 25°C
Index of Refraction 1.551
Storage condition 2-8C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GZ0590030
CHEMICAL NAME :
9,19-Cyclo-5-alpha,9-beta-pregnan-16-alpha-ol, 4,4,14-trimethyl-3-beta,20-alpha-bis (methylamino)-
CAS REGISTRY NUMBER :
860-79-7
LAST UPDATED :
199007
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C26-H46-N2-O
MOLECULAR WEIGHT :
402.74

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
293 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 3,101,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
9200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 3,101,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8900 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 3,101,1982

Chemsrc provides CAS#:860-79-7 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 860-79-7 | Chemsrc address: https://www.chemsrc.com/en/baike/950949.html

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved