Name | 10-[(1-methylpyrrolidin-3-yl)methyl]phenothiazine,hydrochloride |
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Synonyms |
MJ 5022
Bristaline Methdilazine monohydrochloride Methdilazine Hcl 10-(1-methyl-pyrrolidin-3-ylmethyl)-10H-phenothiazine,monohydrochloride Tacaryl hydrochloride Disyncran Dilosyn Methdilazine hydrochloride METHDILAZINE HYDROCHLORIDE |
Description | Methdilazine hydrochloride is an orally active antibiotic (histamine antagonist). Methdilazine hydrochloride can inhibit various mycobacterium with MIC values at 5-15 μg/mL in vitro and in vivo, which can be used for the research of infectious diseases[1][2]. |
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Related Catalog | |
In Vitro | Methdilazine hydrochloride (0-20 μg/mL approximately, 18 h) inhibits kinds of mycobacterium with MIC values ranging from 5 μg/mL to 15 μg/mL[1]. Cell Proliferation Assay[1] Cell Line: M. smegmatis 798/1546, M.,fortuitum 1529, M. scrofulaceum 1323, M. gordonae 1324, M. rnarinum 50, M.,flavescens 1541, M. terrae 1450, M. tuberculosis, H37Ra 16, H37Rv 16, K1, K2, ICRC bacillus,'Skinsnes' bacillus. Concentration: 0-20 μg/mL approximately Incubation Time: 18 h Result: Inhibited mycobacterium with MIC values ranging from 5 μg/mL to 15 μg/mL. |
In Vivo | Methdilazine hydrochloride (Intraperitoneal injection, 10 μg/gm body wt/day, 6 weeks) is antagonistic to mycobacteria in H37Rv infected mice[1]. Methdilazine hydrochloride (Oral administration, 10 mg/kg per day, 28 days) improves survival of Mycobacterium Tuberculosis (Mtb) H37Rv infected mice[2]. Animal Model: H37Rv infected mice[1] Dosage: 10 μg/gm body wt/day, 6 weeks Administration: Intraperitoneal injection Result: Displayed an anti-mycobacterial activity to mycobacteria. Animal Model: Mycobacterium Tuberculosis (Mtb) H37Rv infected Swiss albino male mice[2] Dosage: 10 mg/kg per day for 28 days Administration: Oral administration Result: Increased surviving time to 28 days with no sign of disease, showed 71.42% survival. |
References |
Boiling Point | 430.4ºC at 760mmHg |
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Melting Point | 187.5-189ºC |
Molecular Formula | C18H21ClN2S |
Molecular Weight | 332.89100 |
Flash Point | 214.1ºC |
Exact Mass | 332.11100 |
PSA | 31.78000 |
LogP | 5.04590 |
Vapour Pressure | 1.3E-07mmHg at 25°C |
Index of Refraction | 1.642 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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RIDADR | NONH for all modes of transport |
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HS Code | 2934300000 |
HS Code | 2934300000 |
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Summary | 2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |