125602-71-3

125602-71-3 structure

Name: (S)-Bepotastine
Chemical Name: bepotastine
CAS Number: 125602-71-3
Molecular Formula: C₂₁H₂₅ClN₂O₃
Molecular Weight: 388.888
Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
Create Date: 2018-02-28 08:00:00
Modify Date: 2024-01-03 21:29:52
Bepotastine is an orally active second-generation histamine H1 receptor antagonist. Bepotastine has the potential for allergic rhinitis and urticaria/pruritus treatment[1][2].

Name	bepotastine
Synonyms	(+)-(S)-4-[4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidino]butyric acid monobenzenesulfonate 4-[(S)-(4-chlorophenyl)-2-pyridinylMethoxy] 4-{4-[(S)-(4-Chlorophenyl)(2-pyridinyl)methoxy]-1-piperidinyl}butanoic acid (+)-(S)-4-{4[(4-chlorphenyl)(2-pyridil)methoxy]piperidino}butyric acid monobenzenesulfonate 1-Piperidinebutanoic acid, 4-[(S)-(4-chlorophenyl)-2-pyridinylmethoxy]- 1-Piperidinebutanoic acid,4-[(S)-(4-chlorophenyl)-2-pyridinylmethoxy] 4-[4-[(4-Chlorophenyl)pyridin-2-ylmethoxy]piperidin-1-yl]butanoic acid (+)-(S)-4-[4-[1-(4-chlorophenyl)-1-(2-pyridyl)methoxy]piperidin-1-yl]butyric acid [14C]-Bepotastine besilate Bepotastine 4-(4-[(1S)(4-CHLOROPHENYL)-2-PYRIDYLMETHOXY]PIPERIDYL)BUTANOIC ACID betotastine besilate 4-(4-((S)-(4-Chlorophenyl)(pyridin-2-yl)methoxy)piperidin-1-yl)butanoic Acid (+)-4-(((S)-p-Chloro-2-pyridylbenzyl)oxy)-1-piperidinebutyric Acid betotastine Bepreve 4-{4-[(S)-(4-Chlorophenyl)(pyridin-2-yl)methoxy]piperidin-1-yl}butanoic acid

Description	Bepotastine is an orally active second-generation histamine H1 receptor antagonist. Bepotastine has the potential for allergic rhinitis and urticaria/pruritus treatment[1][2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Endocrinology Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
Target	Histamine H1 receptor[1]
References	[1]. Kanzaki S, et al. Histamine antagonist Bepotastine suppresses nasal symptoms caused by Japanese cedar and cypress pollen exposure. J Drug Assess. 2016 Sep 27;5(1):15-23. [2]. Singh DK, et al. Characterization of Photodegradation Products of Bepotastine Besilate and In silico Evaluation of Their Physicochemical, Absorption, Distribution, Metabolism, Excretion and Toxicity Properties. J Pharm Sci. 2020 Mar 12. pii: S0022-3549(20)30128-3.

Hazard Codes	Xn

1415692-17-9

98-11-3

125602-71-3

~64%

125602-71-3

Literature: Ha, Tae Hee; Suh, Kwee-Hyun; Lee, Gwan Sun Bulletin of the Korean Chemical Society, 2013 , vol. 34, # 2 p. 549 - 552

98-11-3

125602-71-3

~68%

125602-71-3

Literature: Hanmi Pharm. Co., Ltd. Patent: US2010/137367 A1, 2010 ; Location in patent: Page/Page column 3 ;

122368-54-1

125602-71-3

Literature: US2014/46068 A1, ;

4045-22-1

125602-71-3

Literature: US2014/46068 A1, ;

5382-16-1

125602-71-3

Literature: US2014/46068 A1, ;