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526-08-9

526-08-9 structure
526-08-9 structure
  • Name: Sulfaphenazole
  • Chemical Name: sulfaphenazole
  • CAS Number: 526-08-9
  • Molecular Formula: C15H14N4O2S
  • Molecular Weight: 314.362
  • Catalog: API Synthetic anti-infective drugs Sulfonamides and synergists
  • Create Date: 2018-05-31 08:00:00
  • Modify Date: 2024-01-05 07:58:00
  • Sulfaphenazole is a specific inhibitor of CYP2C9 which blocks atherogenic and pro-inflammatory effects of linoleic acid (increase in oxidative stress and activation of AP-1) mediated by CYP2C9. Acts as an antibacterial and antimicrobial.

Name sulfaphenazole
Synonyms Benzenesulfonamide, 4-amino-N-(1-phenyl-1H-pyrazol-5-yl)-
MFCD00057226
EINECS 208-384-3
4-amino-N-(2-phenylpyrazol-3-yl)benzenesulfonamide
4-Amino-N-(1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide
Sulfaphenazole
Description Sulfaphenazole is a specific inhibitor of CYP2C9 which blocks atherogenic and pro-inflammatory effects of linoleic acid (increase in oxidative stress and activation of AP-1) mediated by CYP2C9. Acts as an antibacterial and antimicrobial.
Related Catalog
Density 1.4±0.1 g/cm3
Boiling Point 541.9±56.0 °C at 760 mmHg
Melting Point 179-183ºC
Molecular Formula C15H14N4O2S
Molecular Weight 314.362
Flash Point 281.5±31.8 °C
Exact Mass 314.083740
PSA 98.39000
LogP 1.52
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.684

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DA9520000
CHEMICAL NAME :
Benzenesulfonamide, 4-amino-N-(1-phenyl-1H-pyrazol-5-yl)-
CAS REGISTRY NUMBER :
526-08-9
BEILSTEIN REFERENCE NO. :
0308518
LAST UPDATED :
199612
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C15-H14-N4-O2-S
MOLECULAR WEIGHT :
314.39
WISWESSER LINE NOTATION :
T5NNJ BR& CMSWR DZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,387,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
525 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,387,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3016 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MIMEAO Minerva Medica. (Edizioni Minerva Medica, Casella Postale 491, I-10126 Turin, Italy) V.1- 1909- Volume(issue)/page/year: 52,1789,1961
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
660 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,387,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
470 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,387,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
950 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,387,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
440 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,387,1982
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xn
Safety Phrases 24/25
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS DA9520000
HS Code 2935009090

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526-08-9 structure

526-08-9

Literature: CIBA Patent: US2858309 , 1957 ;
Precursor  1

DownStream  0

HS Code 2935009090
Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%