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Product Name: Sulfaphenazole
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China
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DC Chemicals Limited
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Product Name: Sulfaphenazole
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Dayang Chem (Hangzhou) Co., Ltd.
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526-08-9

526-08-9 structure

Name: Sulfaphenazole
Chemical Name: sulfaphenazole
CAS Number: 526-08-9
Molecular Formula: C₁₅H₁₄N₄O₂S
Molecular Weight: 314.362
Catalog: API Synthetic anti-infective drugs Sulfonamides and synergists
Create Date: 2018-05-31 08:00:00
Modify Date: 2024-01-05 07:58:00
Sulfaphenazole is a specific inhibitor of CYP2C9 which blocks atherogenic and pro-inflammatory effects of linoleic acid (increase in oxidative stress and activation of AP-1) mediated by CYP2C9. Acts as an antibacterial and antimicrobial.

Name	sulfaphenazole
Synonyms	Benzenesulfonamide, 4-amino-N-(1-phenyl-1H-pyrazol-5-yl)- MFCD00057226 EINECS 208-384-3 4-amino-N-(2-phenylpyrazol-3-yl)benzenesulfonamide 4-Amino-N-(1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide Sulfaphenazole

Description	Sulfaphenazole is a specific inhibitor of CYP2C9 which blocks atherogenic and pro-inflammatory effects of linoleic acid (increase in oxidative stress and activation of AP-1) mediated by CYP2C9. Acts as an antibacterial and antimicrobial.
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection

Density	1.4±0.1 g/cm3
Boiling Point	541.9±56.0 °C at 760 mmHg
Melting Point	179-183ºC
Molecular Formula	C₁₅H₁₄N₄O₂S
Molecular Weight	314.362
Flash Point	281.5±31.8 °C
Exact Mass	314.083740
PSA	98.39000
LogP	1.52
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.684

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DA9520000

CHEMICAL NAME :: Benzenesulfonamide, 4-amino-N-(1-phenyl-1H-pyrazol-5-yl)-

CAS REGISTRY NUMBER :: 526-08-9

BEILSTEIN REFERENCE NO. :: 0308518

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C15-H14-N4-O2-S

MOLECULAR WEIGHT :: 314.39

WISWESSER LINE NOTATION :: T5NNJ BR& CMSWR DZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,387,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 525 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,387,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3016 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MIMEAO Minerva Medica. (Edizioni Minerva Medica, Casella Postale 491, I-10126 Turin, Italy) V.1- 1909- Volume(issue)/page/year: 52,1789,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 660 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,387,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 470 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,387,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 950 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,387,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 440 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,387,1982

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn
Safety Phrases	24/25
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	DA9520000
HS Code	2935009090

93880-94-5

526-08-9

Literature: CIBA Patent: US2858309 , 1957 ;

Precursor 1
93880-94-5
DownStream 0

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

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