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143-74-8

143-74-8 structure
143-74-8 structure
  • Name: Phenol red
  • Chemical Name: Phenol red
  • CAS Number: 143-74-8
  • Molecular Formula: C19H14O5S
  • Molecular Weight: 354.376
  • Catalog: API Diagnostic medication Organ function test agent
  • Create Date: 2018-04-09 08:00:00
  • Modify Date: 2024-01-03 09:09:38
  • Phenol red (Phenolsulfonephthalein) is a pH indicator dye, relying on a distinct color change from pink to yellow in case of a positive reaction[1] [2].
Name Phenol red
Synonyms 3,3-bis(p-hydroxyphenyl)-3h-2,1-benzoxathiole 1,1-dioxide
Phenolsulfonphthalein
P.S.P.
a-Hydroxy-a,a-bis(p-hydroxyphenyl)-o-toluenesulfonic Acid g-Sultone
PSP
EINECS 205-609-7
TF-R 2
4-[3-(4-hydroxyphenyl)-1,1-dioxo-2,1λ<sup>6</sup>-benzoxathiol-3-yl]phenol
4,4'-(1,1-Dioxido-3H-2,1-benzoxathiole-3,3-diyl)diphenol
4,4'-(3H-2,1-Benzoxathiol-3-ylidene)bisphenol S,S-Dioxide
Phenol, 4,4'-(1,1-dioxido-3H-2,1-benzoxathiol-3-ylidene)bis-
Phenol red
MFCD00003552
Description Phenol red (Phenolsulfonephthalein) is a pH indicator dye, relying on a distinct color change from pink to yellow in case of a positive reaction[1] [2].
Related Catalog
In Vitro Phenol red (PR) is the standard pH indicator in various cell and tissue culture media, as it provides a quick check for the health of the culture. Phenol red has also been used in multiple protocols to detect cellular hydrogen peroxide as well as peroxidase activity from human peroxidase enzymes[1].
References

[1]. Morgan A, et al. Caution for the routine use of phenol red - It is more than just a pH indicator. Chem Biol Interact. 2019;310:108739.

[2]. Peltzer D, et al. Rapid and simple colorimetric loop-mediated isothermal amplification (LAMP) assay for the detection of Bovine alphaherpesvirus 1. J Virol Methods. 2021;289:114041.
Density 1.5±0.1 g/cm3
Boiling Point 562.8±50.0 °C at 760 mmHg
Melting Point 300 °C
Molecular Formula C19H14O5S
Molecular Weight 354.376
Flash Point 294.2±30.1 °C
Exact Mass 354.056183
PSA 92.21000
LogP 3.02
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.697
Storage condition Store at RT.
Water Solubility 0.77 g/L

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SJ7490000
CHEMICAL NAME :
Phenol, 4,4'-(3H-2,1-benzoxathiol-3-ylidene)di-, S,S-dioxide
CAS REGISTRY NUMBER :
143-74-8
BEILSTEIN REFERENCE NO. :
0326470
LAST UPDATED :
199701
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C19-H14-O5-S
MOLECULAR WEIGHT :
354.39
WISWESSER LINE NOTATION :
T56 BSWO DHJ DR DQ& DR DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
752 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1368 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
1 mg/plate
REFERENCE :
AEMIDF Applied and Environmental Microbiology. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.31- 1976- Volume(issue)/page/year: 42,641,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82224 No. of Facilities: 1719 (estimated) No. of Industries: 16 No. of Occupations: 13 No. of Employees: 5387 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82224 No. of Facilities: 2166 (estimated) No. of Industries: 19 No. of Occupations: 26 No. of Employees: 27087 (estimated) No. of Female Employees: 14345 (estimated)
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S37/39-S26
RIDADR NONH for all modes of transport
RTECS SJ7490000
Packaging Group I; II; III
HS Code 29349990
861784-67-0 structure

861784-67-0

~%

143-74-8 structure

143-74-8

Literature: Journal of the American Chemical Society, , vol. 45, p. 493
81-07-2 structure

81-07-2

108-95-2 structure

108-95-2

~26%

143-74-8 structure

143-74-8

Literature: Tillu; Dumbre; Borate; Wakharkar; Choudhary Synthetic Communications, 2012 , vol. 42, # 8 p. 1101 - 1107
108-95-2 structure

108-95-2

~%

143-74-8 structure

143-74-8

Literature: Journal of the American Chemical Society, , vol. 45, p. 486
81-08-3 structure

81-08-3

108-95-2 structure

108-95-2

~82%

143-74-8 structure

143-74-8

Literature: Cihelnik, Simon; Stibor, Ivan; Lhotak, Pavel Collection of Czechoslovak Chemical Communications, 2002 , vol. 67, # 12 p. 1779 - 1789
HS Code 2934991000
Summary 2934991000. sultones and sultams. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Chemsrc provides CAS#:143-74-8 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 143-74-8 | Chemsrc address: https://www.chemsrc.com/en/baike/951465.html

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