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17780-75-5

17780-75-5 structure
17780-75-5 structure
  • Name: Clorgyline hydrochloride
  • Chemical Name: 3-(2,4-dichlorophenoxy)-N-methyl-N-prop-2-ynylpropan-1-amine,hydrochloride
  • CAS Number: 17780-75-5
  • Molecular Formula: C13H16Cl3NO
  • Molecular Weight: 308.631
  • Catalog: Signaling Pathways Neuronal Signaling Monoamine Oxidase
  • Create Date: 2018-12-27 18:48:11
  • Modify Date: 2024-01-09 15:18:45
  • Clorgyline hydrochloride is an irreversible and selective inhibitor of monoamine oxidase A (MAO-A) that is used in scientific research; structurally related to Pargyline.
Name 3-(2,4-dichlorophenoxy)-N-methyl-N-prop-2-ynylpropan-1-amine,hydrochloride
Synonyms N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride
2-Propyn-1-amine, N-(3-(2,4-dichlorophenoxy)propyl)-N-methyl-, hydrochloride (9CI)
CLORGYLINE HYDROCHLORIDE
Clorgyline HCl
N-[3-(2,4-Dichlorophenoxy)propyl]-N-methylprop-2-yn-1-amine hydrochloride (1:1)
B 9302
2-Propyn-1-amine, N-[3-(2,4-dichlorophenoxy)propyl]-N-methyl-, hydrochloride (1:1)
EINECS 241-760-5
N-[3-(2,4-Dichlorophenoxy)propyl]-N-methyl-2-propyn-1-amine hydrochloride (1:1)
clorgiline hydrochloride
N-[3-(2,4-dichlorophenoxy)propyl]-N-methyl-2-propynylamine hydrochloride
Clorgiline (hydrochloride)
Description Clorgyline hydrochloride is an irreversible and selective inhibitor of monoamine oxidase A (MAO-A) that is used in scientific research; structurally related to Pargyline.
Related Catalog
References

[1]. Murphy DL, et al. Differential trace amine alterations in individuals receiving acetylenic inhibitors of MAO-A (clorgyline) or MAO-B (selegiline and pargyline). Journal of neural transmission. Supplementum 52: 39-48.
Boiling Point 361.3ºC at 760mmHg
Molecular Formula C13H16Cl3NO
Molecular Weight 308.631
Flash Point 172.3ºC
Exact Mass 307.029755
PSA 12.47000
LogP 4.12930
Vapour Pressure 2.1E-05mmHg at 25°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UI0675000
CHEMICAL NAME :
Propylamine, 3-(2,4-dichlorophenoxy)-N-methyl-N-propargyl-, hydrochloride
CAS REGISTRY NUMBER :
17780-75-5
LAST UPDATED :
199509
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C13-H15-Cl2-N-O.Cl-H
MOLECULAR WEIGHT :
308.65
WISWESSER LINE NOTATION :
GR CG DO3N1&2UU1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
210 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 17,1285,1968
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
62 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 17,1285,1968
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
430 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 17,1285,1968
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 21,56,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 17,1285,1968
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
94 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 17,1285,1968
Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301-H312-H332
Precautionary Statements P280-P301 + P310
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xn: Harmful;
Risk Phrases 20/21/22
RIDADR UN 2811 6.1/PG 3
RTECS UI0675000
Packaging Group III
Hazard Class 6.1(b)
HS Code 2922299090
HS Code 2922299090
Summary 2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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