120-21-8

120-21-8 structure

Name: 4-Diethylaminobenzaldehyde
Chemical Name: 4-(diethylamino)benzaldehyde
CAS Number: 120-21-8
Molecular Formula: C₁₁H₁₅NO
Molecular Weight: 177.243
Catalog: Signaling Pathways Metabolic Enzyme/Protease Aldehyde Dehydrogenase (ALDH)
Create Date: 2018-09-20 17:59:43
Modify Date: 2024-01-02 08:49:02
4-Diethylaminobenzaldehyde is a reversible aldehyde dehydrogenases (ALDHs) inhibitor, with a Ki of 4 nM for ALDH1. 4-Diethylaminobenzaldehyde displays potent anti-androgenic effect (IC50= 1.71μM)[1][2].

Name	4-(diethylamino)benzaldehyde
Synonyms	Benzaldehyde, 4-(diethylamino)- MFCD00003382 4-Diethylaminobenzaldehyde 4-Diethylaminobenzoaldehyde 4-(Diethylamino)benzaldehyde EINECS 204-377-4 p-(Diethylamino)benzaldehyde 4-(Diethylamino)-Benzaldehyde Benzaldehyde, p-(diethylamino)-

Description	4-Diethylaminobenzaldehyde is a reversible aldehyde dehydrogenases (ALDHs) inhibitor, with a Ki of 4 nM for ALDH1. 4-Diethylaminobenzaldehyde displays potent anti-androgenic effect (IC50= 1.71μM)[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Aldehyde Dehydrogenase (ALDH) Research Areas >> Cancer
In Vitro	4-Diethylaminobenzaldehyde (DEAB) is reversible competitive inhibitor of ALDH1 (competitive with the aldehyde substrate) with a Ki value of 4 nM, and irreversibly inactivates ALDH7A1 via formation of a stable, covalent acyl-enzyme species[1]. The Temozolomide (TMZ)-resistant cell line LN18 is treated with a combination of TMZ and 4-Diethylaminobenzaldehyde for 10 days. As indicated by colony formation assay, the clonogenic capacity of LN18 cells exposed to TMZ in combination with 4-Diethylaminobenzaldehyde (DEAB) is significantly attenuated[3].
References	[1]. Luo M, et al. Diethylaminobenzaldehyde is a covalent, irreversible inactivator of ALDH7A1. ACS Chem Biol. 2015 Mar 20;10(3):693-7. [2]. Araki N, et al. Screening for androgen receptor activities in 253 industrial chemicals by in vitro reporter gene assays using AR-EcoScreen cells. Toxicol In Vitro. 2005 Sep;19(6):831-42.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H312-H315-H319-H335
Precautionary Statements	P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn:Harmful;N:Dangerousfortheenvironment;
Risk Phrases	R21/22;R50/53
Safety Phrases	S26-S36-S61-S60-S36/37
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	CU5612850
HS Code	2922399090

HS Code	2922399090
Summary	2922399090 other amino-aldehydes, amino-ketones and amino-quinones, other than those containing more than one kind of oxygen function; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%