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1124-11-4

1124-11-4 structure
1124-11-4 structure
  • Name: Tetramethylpyrazine
  • Chemical Name: Tetramethylpyrazine
  • CAS Number: 1124-11-4
  • Molecular Formula: C8H12N2
  • Molecular Weight: 136.19
  • Catalog: API Circulatory system medication Prevention and treatment of angina pectoris
  • Create Date: 2018-07-16 20:23:13
  • Modify Date: 2024-01-02 22:30:26
  • Tetramethylpyrazine (Ligustrazine), an alkylpyrazine isolated from Ligusticum wallichii (Chuan Xiong)[1], is present in french fries, bread, cooked meats, tea, cocoa, coffee, beer, spirits, peanuts, filberts, dairy products and soy products as fragrance and flavouring ingredienexhibits. Tetramethylpyrazine (Ligustrazine) also has potential nootropic and anti-inflammatory activities in rats[2][3].
Name Tetramethylpyrazine
Synonyms Pyrazine, 2,3,5,6-tetramethyl-
MFCD00006146
Chuanxingzine
Ligustrazine
2,3,5,6-Tetramethylpyrazine
EINECS 214-391-2
2,3,5,6,-Tetramethyl-1,4-pyrazine
PPyrazine, tetramethyl-
Tetramethyl-1,4-diazine
Tetramethylpyrazine
2,3,5,6-TETRA METHYL PYRAZINE
Description Tetramethylpyrazine (Ligustrazine), an alkylpyrazine isolated from Ligusticum wallichii (Chuan Xiong)[1], is present in french fries, bread, cooked meats, tea, cocoa, coffee, beer, spirits, peanuts, filberts, dairy products and soy products as fragrance and flavouring ingredienexhibits. Tetramethylpyrazine (Ligustrazine) also has potential nootropic and anti-inflammatory activities in rats[2][3].
Related Catalog
In Vitro Tetramethylpyrazine has been extensively used in China for cardiovascular and cerebrovascular diseases for about 40 years. Because of its effectiveness in multisystem, especially in cardiovascular. Tetramethylpyrazine also has been used in various diseases, such as coronary heart disease, diabetes, cancers, and liver injury[1].
References

[1]. Zhao Y, et al. Mechanisms and Clinical Application of Tetramethylpyrazine (an Interesting Natural Compound Isolated from Ligusticum Wallichii): Current Status and Perspective. Oxid Med Cell Longev. 2016;2016:2124638.

[2]. Wu W, et al. Tetramethylpyrazine protects against scopolamine-induced memory impairments in rats by reversing the cAMP/PKA/CREB pathway. Behav Brain Res. 2013 Sep 15;253:212-6.

[3]. Kao TK, et al. Tetramethylpyrazine reduces cellular inflammatory response following permanent focal cerebral ischemia in rats. Exp Neurol. 2013 Sep;247:188-201.
Density 1.0±0.1 g/cm3
Boiling Point 192.7±35.0 °C at 760 mmHg
Melting Point 77-80 °C(lit.)
Molecular Formula C8H12N2
Molecular Weight 136.19
Flash Point 71.6±17.6 °C
Exact Mass 136.100052
PSA 25.78000
LogP 1.56
Vapour Pressure 0.7±0.4 mmHg at 25°C
Index of Refraction 1.504
Stability Stable. Incompatible with strong acids, strong oxidizing agents.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UQ3905000
CHEMICAL NAME :
Pyrazine, tetramethyl-
CAS REGISTRY NUMBER :
1124-11-4
LAST UPDATED :
199701
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C8-H12-N2
MOLECULAR WEIGHT :
136.22
WISWESSER LINE NOTATION :
T6N DNJ B1 C1 E1 F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1910 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,249,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IJCREE International Journal of Crude Drug Research. (Swets & Zeitlinger B.V., POB 825, 2160 SZ Lisse, Netherlands) V.20- 1982- Volume(issue)/page/year: 23,119,1985
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
239 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CMJODS Chinese Medical Journal (Beijing, English Edition). (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1975- Adopted vol. no. 92 in 1979. Volume(issue)/page/year: 4,319,1978
Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger
Hazard Statements H302-H315-H318-H335
Precautionary Statements P261-P280-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn:Harmful
Risk Phrases R22
Safety Phrases S26-S39-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS UQ3905000
HS Code 29339990
HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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