22425-82-7

22425-82-7 structure

Name: methyl (4aS,6aR,6aS,6bR,10R,11R,12aR,14bR)-10,11-dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate
Chemical Name: methyl (4aS,6aR,6aS,6bR,10R,11R,12aR,14bR)-10,11-dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate
CAS Number: 22425-82-7
Molecular Formula: C₃₁H₅₀O₄
Molecular Weight: 486.72600
Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
Create Date: 2018-07-14 11:27:27
Modify Date: 2024-01-07 18:07:24
Methyl maslinate is a β-adrenergic antagonist. Methyl maslinate is a potent cardiotonic and antidysrhythmic agent. Methyl maslinate has the potential for hypertension research[1].

Name	methyl (4aS,6aR,6aS,6bR,10R,11R,12aR,14bR)-10,11-dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate
Synonyms	Crategolic acid methyl ester Methyl maslinate Maslinic acid methyl ester 2alpha,3beta-Dihydroxyolean-12-en-28-oic acid methyl ester

Description	Methyl maslinate is a β-adrenergic antagonist. Methyl maslinate is a potent cardiotonic and antidysrhythmic agent. Methyl maslinate has the potential for hypertension research[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
In Vivo	Methyl maslinate (MM) (20-60 mg/kg; i.p.) shows significant, dose-dependent vasodepressor effect and sinus bradycardia, lasting more than 60 minutes with a maximum at 20 minutes, and shows potent hymodynamic effect[1]. Methyl maslinate (40 mg/kg) shows antidysrhythmic activity on ischemia-reperfusion dysrhythmia[1]. Animal Model: Wistar male rats (300-320 g)[1] Dosage: 20-60 mg/kg Administration: Intraperitoneal injection; once Result: Showed significant, dose-response vasodepressor effect and sinus bradicardia. Antagonized β-Adrenergic. Showed antidysrhythmic activity.
References	[1]. Somova LI, et al. Cardiotonic and antidysrhythmic effects of oleanolic and ursolic acids, methyl maslinate and uvaol. Phytomedicine. 2004 Feb;11(2-3):121-9.

Precursor 0
DownStream 4
14464-51-8 4373-41-5 1724-17-0 545-48-2