Name | 8-[3-(2-chlorophenothiazin-10-yl)propyl]-1-thia-4,8-diazaspiro[4.5]decan-3-one |
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Synonyms |
Spiclomazine [INN]
Clospirazine Spiclomazinum [INN-Latin] Spiclomazinum Espiclomazina Spiclomazine |
Description | Spiclomazine (Clospirazine) is a potent mutant KRAS(G12C) inhibitor that selectively inhibits mutant KRAS-driven pancreatic cancer. Spiclomazine can eliminate KRas-GTP levels in KRAS-driven pancreatic cancer and effectively inhibit RAS-mediated signaling. Spiclomazine significantly inhibits tumor progression in mouse renal capsule xenotransplantation models[1]. |
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Related Catalog | |
Target |
KRAS(G12C) |
References |
Density | 1.42g/cm3 |
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Boiling Point | 695.3ºC at 760mmHg |
Molecular Formula | C22H24ClN3OS2 |
Molecular Weight | 446.03 |
Flash Point | 374.3ºC |
Exact Mass | 445.10500 |
PSA | 86.18000 |
LogP | 5.31960 |
Vapour Pressure | 3.51E-19mmHg at 25°C |
Index of Refraction | 1.724 |