Top Suppliers:I want be here

  • DC Chemicals Limited
  • China
  • Product Name: NSC290956
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

24527-27-3

24527-27-3 structure
24527-27-3 structure
  • Name: spiclomazine
  • Chemical Name: 8-[3-(2-chlorophenothiazin-10-yl)propyl]-1-thia-4,8-diazaspiro[4.5]decan-3-one
  • CAS Number: 24527-27-3
  • Molecular Formula: C22H24ClN3OS2
  • Molecular Weight: 446.03
  • Create Date: 2018-08-05 10:07:23
  • Modify Date: 2024-01-06 17:20:08
  • Spiclomazine (Clospirazine) is a potent mutant KRAS(G12C) inhibitor that selectively inhibits mutant KRAS-driven pancreatic cancer. Spiclomazine can eliminate KRas-GTP levels in KRAS-driven pancreatic cancer and effectively inhibit RAS-mediated signaling. Spiclomazine significantly inhibits tumor progression in mouse renal capsule xenotransplantation models[1].

Name 8-[3-(2-chlorophenothiazin-10-yl)propyl]-1-thia-4,8-diazaspiro[4.5]decan-3-one
Synonyms Spiclomazine [INN]
Clospirazine
Spiclomazinum [INN-Latin]
Spiclomazinum
Espiclomazina
Spiclomazine
Description Spiclomazine (Clospirazine) is a potent mutant KRAS(G12C) inhibitor that selectively inhibits mutant KRAS-driven pancreatic cancer. Spiclomazine can eliminate KRas-GTP levels in KRAS-driven pancreatic cancer and effectively inhibit RAS-mediated signaling. Spiclomazine significantly inhibits tumor progression in mouse renal capsule xenotransplantation models[1].
Related Catalog
Target

KRAS(G12C)

References

[1]. Guo X, et al. Spiclomazine displays a preferential anti-tumor activity in mutant KRas-driven pancreatic cancer. Oncotarget. 2018 Jan 8;9(6):6938-6951.  

Density 1.42g/cm3
Boiling Point 695.3ºC at 760mmHg
Molecular Formula C22H24ClN3OS2
Molecular Weight 446.03
Flash Point 374.3ºC
Exact Mass 445.10500
PSA 86.18000
LogP 5.31960
Vapour Pressure 3.51E-19mmHg at 25°C
Index of Refraction 1.724