Name | dothiepin |
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Synonyms |
1-Propanamine, 3-dibenzo[b,e]thiepin-11(6H)-ylidene-N,N-dimethyl-, (3E)-
11-(3-Dimethylamino-propyliden)-6,11-dihydro-dibenzo<b.e>thiepin Methiaden Dothiepin Dolsulepine Dosulepin Prothiadene Dosulepine 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenzo(b,e)thiepin (3E)-3-(Dibenzo[b,e]thiepin-11(6H)-ylidene)-N,N-dimethyl-1-propanamine досулепин iz914 Dothep trans-dothiepin Prothiaden 11(16H)-(3-[dimethylamino]propylidene)dibenz[b,e]thiopine EINECS 204-031-2 |
Description | Dothiepin (Dosulepin; Dothep) is an antidepressant agent with sedative/anxiolytic activity. Dothiepin is an inhibitor preferring of noradrenaline uptake than serotonin uptake. Dothiepin facilitates noradrenergic neurotransmission via inhibiting the neuronal uptake. Dothiepin is also an antagonist of histamine H1-receptor without cardiotoxicity. Dothiepin exhibits significant analgesic activity in psychogenic facial pain,idiopathic fibromyalgia syndrome or rheumatoid arthritis[1]. |
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Related Catalog | |
Target |
Histamine H1-receptor, Noradrenaline uptake (α1-and α2-adrenoceptors and serotonin 5HT1 and 5HT2-receptors)[1] |
References |
Density | 1.1±0.1 g/cm3 |
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Boiling Point | 430.9±44.0 °C at 760 mmHg |
Melting Point | 55-57ºC |
Molecular Formula | C19H21NS |
Molecular Weight | 295.44 |
Flash Point | 214.4±28.4 °C |
Exact Mass | 295.139465 |
PSA | 28.54000 |
LogP | 4.34 |
Vapour Pressure | 0.0±1.0 mmHg at 25°C |
Index of Refraction | 1.661 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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RIDADR | UN 3249 |
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Packaging Group | III |
Hazard Class | 6.1(b) |
~% 113-53-1 |
Literature: WO2007/136743 A2, ; Page/Page column 20-21 ; |