DC Chemicals Limited
China
Product Name: Norfluoxetine hydrochloride
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

57226-68-3

57226-68-3 structure

Name: Norfluoxetine hydrochloride
Chemical Name: Norfluoxetine hydrochloride
CAS Number: 57226-68-3
Molecular Formula: C₁₆H₁₇ClF₃NO
Molecular Weight: 331.760
Catalog: analytical chemistry Analytical reagent Ion chromatography reagent
Create Date: 2017-06-27 05:29:30
Modify Date: 2024-01-04 12:05:10
Norfluoxetine hydrochloride is an active N-demethylated metabolite of Fluoxetine. Fluoxetine is a selective serotonin (5-HT) reuptake inhibitor that is metabolized to Norfluoxetine hydrochloride by cytochrome P450 (CYP) 2D6, CYP2C19, and CYP3A4. Norfluoxetine hydrochloride inhibits 5-HT uptake and inhibits CaV3.3 T current (IC50 = 5 μM). Norfluoxetine hydrochloride has anticonvulsant activity[1][2][3][4].

Name	Norfluoxetine hydrochloride
Synonyms	3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine,hydrochloride Benzenepropanamine, γ-(4-(trifluoromethyl)phenoxy)-, hydrochloride 3-Phenyl-3-[4-(trifluoromethyl)phenoxy]-1-propanamine hydrochloride (1:1) Benzenepropanamine, γ-[4-(trifluoromethyl)phenoxy]-, hydrochloride (1:1)

Description	Norfluoxetine hydrochloride is an active N-demethylated metabolite of Fluoxetine. Fluoxetine is a selective serotonin (5-HT) reuptake inhibitor that is metabolized to Norfluoxetine hydrochloride by cytochrome P450 (CYP) 2D6, CYP2C19, and CYP3A4. Norfluoxetine hydrochloride inhibits 5-HT uptake and inhibits CaV3.3 T current (IC50 = 5 μM). Norfluoxetine hydrochloride has anticonvulsant activity[1][2][3][4].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	5-HT Receptor Cav3.3:5 μM (IC50)
In Vivo	Pretreatment with Fluoxetine or Norfluoxetine hydrochloride (20mg/kg s.c.), as well as Phenytoin (30 mg/kg s.c.) and Clonazepam (0.1mg/kg s.c.) significantly increases both the rate and duration of survival, demonstrating a significant protective effect against Pentylenetetrazol-induced epilepsy[1].
References	[1]. Valéria Kecskeméti, et al. Norfluoxetine and fluoxetine have similar anticonvulsant and Ca2+ channel blocking potencies. Brain Res Bull. 2005 Sep 30;67(1-2):126-32. [2]. Achraf Traboulsie, et al. T-type calcium channels are inhibited by fluoxetine and its metabolite norfluoxetine. Mol Pharmacol. 2006 Jun;69(6):1963-8. [3]. Hyeon-Cheol Jeong, et al. Prediction of Fluoxetine and Norfluoxetine Pharmacokinetic Profiles Using Physiologically Based Pharmacokinetic Modeling. Clin Pharmacol. 2021 Nov;61(11):1505-1513. [4]. D T Wong, et al. Norfluoxetine enantiomers as inhibitors of serotonin uptake in rat brain. Neuropsychopharmacology. 1993 Jun;8(4):337-44.

Density	1.204g/cm3
Boiling Point	381.1ºC at 760 mmHg
Molecular Formula	C₁₆H₁₇ClF₃NO
Molecular Weight	331.760
Flash Point	184.3ºC
Exact Mass	331.095062
PSA	35.25000
LogP	5.67660
Water Solubility	H2O: >4 mg/mL

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3

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