Name | 4-hydroxytolbutamide |
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Synonyms |
1-Butyl-3-(4-hydroxymethylphenyl)sulfonylurea
Benzenesulfonamide, N-[(butylamino)carbonyl]-4-(hydroxymethyl)- hydroxymethyl-TB 4-OH-tolbutamide Methylhydroxytolbutamide hydroxymethyltolbutamide Hydroxytolbutamide 4-Hydroxytolbutamide 4 hydroxy tolbutamide N-(Butylcarbamoyl)-4-(hydroxymethyl)benzenesulfonamide [14C]-Hydroxytolbutamide N-(Butylaminocarbonyl)-4-hydroxymethylbenzenesulfonamide 1-butyl-3-[4-(hydroxymethyl)phenyl]sulfonylurea |
Description | 4-Hydroxytolbutamide (Hydroxytolbutamide) is a metabolite of Tolbutamide. 4-Hydroxytolbutamide is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic[1][2]. |
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Related Catalog | |
Target |
Potassium channel |
References |
Density | 1.3±0.1 g/cm3 |
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Melting Point | 100-102ºC |
Molecular Formula | C12H18N2O4S |
Molecular Weight | 286.347 |
Flash Point | 2℃ |
Exact Mass | 286.098724 |
PSA | 103.88000 |
LogP | 0.70 |
Index of Refraction | 1.553 |
Storage condition | 2-8°C |
Water Solubility | ethanol: 12 mg/mL |
Symbol |
GHS02, GHS07 |
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Signal Word | Danger |
Hazard Statements | H225-H302 + H312 + H332-H319 |
Precautionary Statements | P210-P261-P302 + P352 + P312-P304 + P340 + P312-P337 + P313-P403 + P235 |
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
Hazard Codes | F,Xn |
Risk Phrases | 11-20/21/22-36 |
Safety Phrases | 16-36/37-24/25 |
RIDADR | UN 1648 3 / PGII |
WGK Germany | 3 |
HS Code | 29350090 |
~82% 5719-85-7 |
Literature: Makaya; Irie; Shibasaki Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 7 p. 2518 - 2519 |
~% 5719-85-7 |
Literature: Xenobiotica, , vol. 25, # 12 p. 1345 - 1354 |
~% 5719-85-7 |
Literature: Chemical and Pharmaceutical Bulletin, , vol. 31, # 7 p. 2518 - 2519 |
~% 5719-85-7 |
Literature: Chemical and Pharmaceutical Bulletin, , vol. 31, # 7 p. 2518 - 2519 |
Precursor 4 | |
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DownStream 1 | |