10138-52-0

10138-52-0 structure

Name: gadolinium chloride
Chemical Name: gadolinium trichloride
CAS Number: 10138-52-0
Molecular Formula: Cl₃Gd
Molecular Weight: 263.60900
Catalog: Inorganic chemical industry Inorganic salt Metal halides and halides Metal chlorides and salts
Create Date: 2018-09-20 11:04:45
Modify Date: 2024-01-06 09:47:54
Gadolinium chloride is a specific calcium-sensing receptor (CaSR) agonist. Gadolinium chloride can be used for the research of cardiovascular disease[1].

Name	gadolinium trichloride
Synonyms	trichlorogadolinium EINECS 233-386-6 Gadolinium(Iii) Chloride,Ultra Dry,Reo) Gadolinium(III) chloride MFCD00011024

Description	Gadolinium chloride is a specific calcium-sensing receptor (CaSR) agonist. Gadolinium chloride can be used for the research of cardiovascular disease[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> CaSR
Target	CaSR[1]
In Vitro	Gadolinium chloride (30 μM; 15 minutes; H9c2 cells) results in increased Bax expression and caspase-3 activation, and decreased Bcl-2 expression in CsA-induced cells[1]. In vitro, GdCl3, a CaSR agonist, has been shown to promote the apoptosis of myocardial cells, which increases ERK1/2 phosphorylation and activates caspase-3[1]. Western Blot Analysis[1] Cell Line: H9c2 cells Concentration: 30 μM Incubation Time: 15 minutes Result: Resulted in increased Bax expression and caspase-3 activation, and decreased Bcl-2 expression in CsA-induced cells.
References	[1]. Li X, et al. Calcium Oxalate Induces Renal Injury through Calcium-Sensing Receptor. Oxid Med Cell Longev. 2016;2016:5203801.

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 17,526,1961

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 17,526,1961 ** ACUTE TOXICITY DATA **

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 17,526,1961

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Lungs, Thorax, or Respiration - other changes

REFERENCE :: AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 5,437,1962 *** REVIEWS *** TOXICOLOGY REVIEW JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 54,663,1965

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R38
Safety Phrases	36/37
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	ZC0230000

114364-08-8

10138-52-0

Literature: Thermochimica Acta, , vol. 320, # 1-2 p. 1 - 7