1208549-68-1

1208549-68-1 structure

Name: sEH inhibitor-1
Chemical Name: 1-(1-(cyclopropanecarbonyl)piperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea
CAS Number: 1208549-68-1
Molecular Formula: C₁₇H₂₀F₃N₃O₃
Molecular Weight: 371.354
Catalog: Research Areas Inflammation/Immunology
Create Date: 2017-03-13 12:57:23
Modify Date: 2024-01-12 20:38:41
sEH inhibitor-1 (compound TCPU ) is a potent and oral active inhibitor of sEH (soluble epoxide hydrolase) with IC50s of 0.4 and 5.3 nM in human and murine, respectively[1].

Name	1-(1-(cyclopropanecarbonyl)piperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea
Synonyms	Urea, N-[1-(cyclopropylcarbonyl)-4-piperidinyl]-N'-[4-(trifluoromethoxy)phenyl]- 1-[1-(Cyclopropylcarbonyl)-4-piperidinyl]-3-[4-(trifluoromethoxy)phenyl]urea

Description	sEH inhibitor-1 (compound TCPU ) is a potent and oral active inhibitor of sEH (soluble epoxide hydrolase) with IC50s of 0.4 and 5.3 nM in human and murine, respectively[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
Target	sEH[1]
References	[1]. Liu JY, et al. Substituted phenyl groups improve the pharmacokinetic profile and anti-inflammatory effect of urea-based soluble epoxide hydrolase inhibitors in murine models. Eur J Pharm Sci. 2013;48(4-5):619-627.