64907-22-8

64907-22-8 structure

Name: (3β,7α)-Cholest-5-ene-3,7,25-triol
Chemical Name: 7α,25-Dihydroxycholesterol
CAS Number: 64907-22-8
Molecular Formula: C₂₇H₄₆O₃
Molecular Weight: 418.652
Catalog: Signaling Pathways GPCR/G Protein EBI2/GPR183
Create Date: 2016-09-08 15:28:59
Modify Date: 2024-01-05 11:12:59
7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol is highly potent at activating EBI2 (EC50=140 pM; Kd=450 pM). 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells[1][2].

Name	7α,25-Dihydroxycholesterol
Synonyms	Cholest-5-ene-3,7,25-triol, (3β,7α)- 7.α.,25-dihydroxy Cholesterol (3β,7α)-Cholest-5-ene-3,7,25-triol

Description	7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol is highly potent at activating EBI2 (EC50=140 pM; Kd=450 pM). 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> EBI2/GPR183
Target	Human Endogenous Metabolite
In Vitro	In vitro, 7α, 25-dihydroxycholesterol (7α,25-OHC) stimulates the migration of EBI2-expressing mouse B and T cells with half-maximum effective concentration values around 500 pM, but had no effect on EBI2-deficient cells[1].
In Vivo	EBI2-deficient B cells or normal B cells desensitized by 7α,25-Dihydroxycholesterol (1 μM; 1.5 hours) pre-treatment shows reduced homing to follicular areas of the spleen[1].
References	[1]. Liu C, et al. Oxysterols direct B-cell migration through EBI2. Nature. 2011 Jul 27;475(7357):519-23. [2]. Hannedouche S, et al. Oxysterols direct immune cell migration via EBI2. Nature. 2011 Jul 27;475(7357):524-7.

RIDADR	NONH for all modes of transport