Top Suppliers:I want be here



87862-25-7

87862-25-7 structure
87862-25-7 structure
  • Name: Iobenguane sulfate
  • Chemical Name: 1-(3-Iodobenzyl)guanidine sulfate (2:1)
  • CAS Number: 87862-25-7
  • Molecular Formula: C8H10IN3.1/2H2O4S
  • Molecular Weight: 648.25800
  • Catalog: Research Areas Cancer
  • Create Date: 2017-03-13 05:09:15
  • Modify Date: 2024-01-07 20:03:01
  • Iobenguane sulfate (MIBG sulfate) is an analogue of the neurotransmitter norepinephrine with antitumor activity. Radioiodinated Iobenguane sulfate is clinically used as a tumor-targeted radiopharmaceutical in the diagnosis and treatment of adrenergic tumors. Iobenguane sulfate is a high-affinity substrate for cholera toxin that interferes with cellular mono(ADP-ribosylation)[1][2].

Name 1-(3-Iodobenzyl)guanidine sulfate (2:1)
Description Iobenguane sulfate (MIBG sulfate) is an analogue of the neurotransmitter norepinephrine with antitumor activity. Radioiodinated Iobenguane sulfate is clinically used as a tumor-targeted radiopharmaceutical in the diagnosis and treatment of adrenergic tumors. Iobenguane sulfate is a high-affinity substrate for cholera toxin that interferes with cellular mono(ADP-ribosylation)[1][2].
Related Catalog
In Vitro Iobenguane sulfate (MIBG sulfate) (2-20 μg/ml; 72 hours) inhibits cell growth in a panel of human and mouse leukemia, fibrosarcoma, melanoma, and neuroblastoma cell lines[1]. Iobenguane sulfate (MIBG sulfate) is a potent affector of endogenous mono(ADP-ribosyl) transferases of turkey and human erythrocyte membranes, exerting its effect in the μM concentration range[2]. Cell Proliferation Assay[1] Cell Line: 3T3, 3T3-Tl3, BHK, Py-BHK, K562, L1210, RIF1, M5A, B16, LAN-1, N1E115, CHP212 cells Concentration: 2, 20μg/ml Incubation Time: 72 hours Result: Inhibits 3T3, 3T3-Tl3, BHK, Py-BHK, K562, L1210, RIF1, M5A, B16, LAN-1, N1E115, and CHP212 cells growth.
In Vivo Iobenguane sulfate (MIBG hemisulfate) (20 mg/kg; i.p.; daily on days 3-6) shows antitumor activity[1]. The survival of male strain AF mice inoculates with N1E115 neuroblastoma and treats according to NIH protocols for new drug testing with 9 daily injections of Iobenguane sulfate (40 mg/kg), Marking prolongation of sugvival but no cures were observed[1]. Iobenguane sulfate testes for its toxicity on male strain AF (N1Ell5) mice with 5 daily injections. At 50 mg/kg body weight, all animals died after 1-4 doses and 4/16 animals died on a schedule of 44 mg/kg[1]. Animal Model: DBA/2 (L1210)) mice[1] Dosage: i.p.; daily on days 3-6 Administration: 20 mg/kg Result: Considerable prolongation of survival and some cures were obtained.
References

[1]. Loesberg C, et al. Meta-iodobenzylguanidine (MIBG), a novel high-affinity substrate for cholera toxin that interferes with cellular mono(ADP-ribosylation). Biochim Biophys Acta. 1990 Jan 19;1037(1):92-9.

Molecular Formula C8H10IN3.1/2H2O4S
Molecular Weight 648.25800
Exact Mass 647.95100
PSA 206.78000
LogP 5.35840