87862-25-7
87862-25-7 structure
- Name: Iobenguane sulfate
- Chemical Name: 1-(3-Iodobenzyl)guanidine sulfate (2:1)
- CAS Number: 87862-25-7
- Molecular Formula: C8H10IN3.1/2H2O4S
- Molecular Weight: 648.25800
- Catalog: Research Areas Cancer
- Create Date: 2017-03-13 05:09:15
- Modify Date: 2024-01-07 20:03:01
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Iobenguane sulfate (MIBG sulfate) is an analogue of the neurotransmitter norepinephrine with antitumor activity. Radioiodinated Iobenguane sulfate is clinically used as a tumor-targeted radiopharmaceutical in the diagnosis and treatment of adrenergic tumors. Iobenguane sulfate is a high-affinity substrate for cholera toxin that interferes with cellular mono(ADP-ribosylation)[1][2].
| Name | 1-(3-Iodobenzyl)guanidine sulfate (2:1) |
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| Description | Iobenguane sulfate (MIBG sulfate) is an analogue of the neurotransmitter norepinephrine with antitumor activity. Radioiodinated Iobenguane sulfate is clinically used as a tumor-targeted radiopharmaceutical in the diagnosis and treatment of adrenergic tumors. Iobenguane sulfate is a high-affinity substrate for cholera toxin that interferes with cellular mono(ADP-ribosylation)[1][2]. |
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| Related Catalog | |
| In Vitro | Iobenguane sulfate (MIBG sulfate) (2-20 μg/ml; 72 hours) inhibits cell growth in a panel of human and mouse leukemia, fibrosarcoma, melanoma, and neuroblastoma cell lines[1]. Iobenguane sulfate (MIBG sulfate) is a potent affector of endogenous mono(ADP-ribosyl) transferases of turkey and human erythrocyte membranes, exerting its effect in the μM concentration range[2]. Cell Proliferation Assay[1] Cell Line: 3T3, 3T3-Tl3, BHK, Py-BHK, K562, L1210, RIF1, M5A, B16, LAN-1, N1E115, CHP212 cells Concentration: 2, 20μg/ml Incubation Time: 72 hours Result: Inhibits 3T3, 3T3-Tl3, BHK, Py-BHK, K562, L1210, RIF1, M5A, B16, LAN-1, N1E115, and CHP212 cells growth. |
| In Vivo | Iobenguane sulfate (MIBG hemisulfate) (20 mg/kg; i.p.; daily on days 3-6) shows antitumor activity[1]. The survival of male strain AF mice inoculates with N1E115 neuroblastoma and treats according to NIH protocols for new drug testing with 9 daily injections of Iobenguane sulfate (40 mg/kg), Marking prolongation of sugvival but no cures were observed[1]. Iobenguane sulfate testes for its toxicity on male strain AF (N1Ell5) mice with 5 daily injections. At 50 mg/kg body weight, all animals died after 1-4 doses and 4/16 animals died on a schedule of 44 mg/kg[1]. Animal Model: DBA/2 (L1210)) mice[1] Dosage: i.p.; daily on days 3-6 Administration: 20 mg/kg Result: Considerable prolongation of survival and some cures were obtained. |
| References |
| Molecular Formula | C8H10IN3.1/2H2O4S |
|---|---|
| Molecular Weight | 648.25800 |
| Exact Mass | 647.95100 |
| PSA | 206.78000 |
| LogP | 5.35840 |