4431-42-9

4431-42-9 structure

Name: Isopedicin
Chemical Name: 2,4,6-Trimethylbenzamide
CAS Number: 4431-42-9
Molecular Formula: C₁₈H₁₈O₆
Molecular Weight: 330.33
Catalog: Natural product Flavonoids
Create Date: 2017-12-13 08:49:55
Modify Date: 2024-01-09 18:20:52
Isopedicin potently and concentration-dependently inhibits superoxide anion (O2 U?) production in formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP)-activated cells. Isopedicin increases cAMP formation and PKA activity in FMLP-activated cells by inhibiting phosphodiesterase (PDE) activity[1].

Name	2,4,6-Trimethylbenzamide
Synonyms	6-Hydroxy-5,7,8-trimethoxy-2-phenyl-chroman-4-on 4H-1-Benzopyran-4-one, 2,3-dihydro-6-hydroxy-5,7,8-trimethoxy-2-phenyl-, (2S)- 6-Hydroxy-5,5-dimethyl-5,6-dihydro-benz<c>acridin 5,5-Dimethyl-6-hydroxy-5,6-dihydrobenz<c>acridin 6-hydroxy-5,7,8-trimethoxy-2-phenyl-chroman-4-one (2S)-6-Hydroxy-5,7,8-trimethoxy-2-phenyl-2,3-dihydro-4H-chromen-4-one

Description	Isopedicin potently and concentration-dependently inhibits superoxide anion (O2 U?) production in formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP)-activated cells. Isopedicin increases cAMP formation and PKA activity in FMLP-activated cells by inhibiting phosphodiesterase (PDE) activity[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Metabolic Disease
References	[1]. Hwang TL, et al. Potent inhibition of superoxide anion production in activated human neutrophils by isopedicin, a bioactive component of the Chinese medicinal herb Fissistigma oldhamii. Free Radic Biol Med. 2009 Feb 15;46(4):520-8.