215803-78-4
215803-78-4 structure
- Name: SB-277011
- Chemical Name: N-[4-[2-(6-cyano-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]cyclohexyl]quinoline-4-carboxamide
- CAS Number: 215803-78-4
- Molecular Formula: C28H30N4O
- Molecular Weight: 438.564
- Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
- Create Date: 2018-12-25 15:50:43
- Modify Date: 2024-01-10 15:25:50
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SB-277011 is a potent and delective dopamine D3 receptor antagonist (pKi values are 8.0, 6.0, 5.0 and <5.2 for D3, D2, 5-HT1D and 5-HT1B respectively); brain penetrant.IC50 value: 8.0 (pKi)Target: D3 receptor
| Name | N-[4-[2-(6-cyano-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]cyclohexyl]quinoline-4-carboxamide |
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| Synonyms |
N-{trans-4-[2-(6-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl}-4-quinolinecarboxamide
cc-478 4-Quinolinecarboxamide, N-[trans-4-[2-(6-cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]- N-{trans-4-[2-(6-cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl]cyclohexyl}quinoline-4-carboxamide SB-277011 |
| Description | SB-277011 is a potent and delective dopamine D3 receptor antagonist (pKi values are 8.0, 6.0, 5.0 and <5.2 for D3, D2, 5-HT1D and 5-HT1B respectively); brain penetrant.IC50 value: 8.0 (pKi)Target: D3 receptor |
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| Related Catalog | |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 679.3±55.0 °C at 760 mmHg |
| Molecular Formula | C28H30N4O |
| Molecular Weight | 438.564 |
| Flash Point | 364.6±31.5 °C |
| Exact Mass | 438.241974 |
| PSA | 69.02000 |
| LogP | 4.26 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.656 |
| Storage condition | 2-8℃ |