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508-44-1

508-44-1 structure
508-44-1 structure
  • Name: Anemonine
  • Chemical Name: 1,7-Dioxadispiro[4.0.4.2]dodeca-3,9-diene-2,8-dione
  • CAS Number: 508-44-1
  • Molecular Formula: C10H8O4
  • Molecular Weight: 192.17
  • Catalog: Signaling Pathways Epigenetics PKC
  • Create Date: 2018-09-04 12:22:12
  • Modify Date: 2024-01-12 07:26:18
  • Anemonin (Pulsatilla camphor), a selective iNOS inhibitor, is also a PKC-θ inhibitor. Anemonin can significantly inhibit the translation or protein stability of PKC-θ protein. Anemonin also ameliorates dextran sodium sulfate-induced acute ulcerative colitis (UC) in mice. Anemonin can be used in the research of inflammation-related diseases[1][2].
Name 1,7-Dioxadispiro[4.0.4.2]dodeca-3,9-diene-2,8-dione
Synonyms 1,7-Dinitro-naphthalin
1,7-dinitro-naphthalene
1,7-dioxa-dispiro[4.0.4.2]dodeca-3,9-diene-2,8-dione
Naphthalene,1,7-dinitro
1,7-Dioxa-dispiro[4.0.4.2]dodeca-3,9-dien-2,8-dion
Anemonine
Description Anemonin (Pulsatilla camphor), a selective iNOS inhibitor, is also a PKC-θ inhibitor. Anemonin can significantly inhibit the translation or protein stability of PKC-θ protein. Anemonin also ameliorates dextran sodium sulfate-induced acute ulcerative colitis (UC) in mice. Anemonin can be used in the research of inflammation-related diseases[1][2].
Related Catalog
References

[1]. Jiang L, et al. Anti-inflammatory effects of anemonin on acute ulcerative colitis via targeted regulation of protein kinase C-θ. Chin Med. 2022 Mar 28;17(1):39.  

[2]. Lee TH, et al. Anemonin, from Clematis crassifolia, potent and selective inducible nitric oxide synthase inhibitor. J Ethnopharmacol. 2008 Mar 28;116(3):518-27.  

Density 1.45
Boiling Point 535.7ºC at 760 mmHg
Melting Point 157-158ºC
Molecular Formula C10H8O4
Molecular Weight 192.17
Flash Point 300.7ºC
Exact Mass 192.04200
PSA 52.60000
LogP 0.48380
Index of Refraction 1.61

CHEMICAL IDENTIFICATION

RTECS NUMBER :
JG7875000
CHEMICAL NAME :
1,7-Dioxadispiro(4.0.4.2)dodeca-3,9-diene-2,8-dione, trans-
CAS REGISTRY NUMBER :
508-44-1
BEILSTEIN REFERENCE NO. :
0009390
LAST UPDATED :
199709
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C10-H8-O4
MOLECULAR WEIGHT :
192.18
WISWESSER LINE NOTATION :
T5VOXJ C-& AL4XXTJ B-& CT5VOXJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 2,109,1946
Precursor  0

DownStream  3


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