Anemonine

Modify Date: 2024-01-12 07:26:18

Anemonine structure	Common Name	Anemonine
	CAS Number	508-44-1	Molecular Weight	192.17
	Density	1.45	Boiling Point	535.7ºC at 760 mmHg
	Molecular Formula	C₁₀H₈O₄	Melting Point	157-158ºC
	MSDS	N/A	Flash Point	300.7ºC

Use of Anemonine

Anemonin (Pulsatilla camphor), a selective iNOS inhibitor, is also a PKC-θ inhibitor. Anemonin can significantly inhibit the translation or protein stability of PKC-θ protein. Anemonin also ameliorates dextran sodium sulfate-induced acute ulcerative colitis (UC) in mice. Anemonin can be used in the research of inflammation-related diseases[1][2].

Name	1,7-Dioxadispiro[4.0.4.2]dodeca-3,9-diene-2,8-dione
Synonym	More Synonyms

Description	Anemonin (Pulsatilla camphor), a selective iNOS inhibitor, is also a PKC-θ inhibitor. Anemonin can significantly inhibit the translation or protein stability of PKC-θ protein. Anemonin also ameliorates dextran sodium sulfate-induced acute ulcerative colitis (UC) in mice. Anemonin can be used in the research of inflammation-related diseases[1][2].
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Signaling Pathways >> Immunology/Inflammation >> NO Synthase Research Areas >> Inflammation/Immunology Signaling Pathways >> TGF-beta/Smad >> PKC
References	[1]. Jiang L, et al. Anti-inflammatory effects of anemonin on acute ulcerative colitis via targeted regulation of protein kinase C-θ. Chin Med. 2022 Mar 28;17(1):39. [2]. Lee TH, et al. Anemonin, from Clematis crassifolia, potent and selective inducible nitric oxide synthase inhibitor. J Ethnopharmacol. 2008 Mar 28;116(3):518-27.

Description

Related Catalog

Signaling Pathways >> Epigenetics >> PKC

Signaling Pathways >> Immunology/Inflammation >> NO Synthase

Research Areas >> Inflammation/Immunology

Signaling Pathways >> TGF-beta/Smad >> PKC

References

[1]. Jiang L, et al. Anti-inflammatory effects of anemonin on acute ulcerative colitis via targeted regulation of protein kinase C-θ. Chin Med. 2022 Mar 28;17(1):39.

[2]. Lee TH, et al. Anemonin, from Clematis crassifolia, potent and selective inducible nitric oxide synthase inhibitor. J Ethnopharmacol. 2008 Mar 28;116(3):518-27.

Density	1.45
Boiling Point	535.7ºC at 760 mmHg
Melting Point	157-158ºC
Molecular Formula	C₁₀H₈O₄
Molecular Weight	192.17
Flash Point	300.7ºC
Exact Mass	192.04200
PSA	52.60000
LogP	0.48380
Index of Refraction	1.61

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JG7875000

CHEMICAL NAME :: 1,7-Dioxadispiro(4.0.4.2)dodeca-3,9-diene-2,8-dione, trans-

CAS REGISTRY NUMBER :: 508-44-1

BEILSTEIN REFERENCE NO. :: 0009390

LAST UPDATED :: 199709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H8-O4

MOLECULAR WEIGHT :: 192.18

WISWESSER LINE NOTATION :: T5VOXJ C-& AL4XXTJ B-& CT5VOXJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 2,109,1946