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343306-71-8

343306-71-8 structure
343306-71-8 structure
  • Name: Sugammadex
  • Chemical Name: Org 25969
  • CAS Number: 343306-71-8
  • Molecular Formula: C72H104Na8O48S8
  • Molecular Weight: 2002.151
  • Catalog: Research Areas Cardiovascular Disease
  • Create Date: 2017-12-09 23:51:42
  • Modify Date: 2024-01-03 17:30:11
  • Sugammadex is a synthetic γ-cyclodextrin derivative, and acts as a reversal agent for neuromuscular block. Sugammadex shows nephroprotective effect in ischemia-reperfusion injury[1][2].

Name Org 25969
Synonyms 3,3',3'',3''',3'''',3''''',3'''''',3'''''''-{[(1S,3S,5S,6S,8S,10S,11S,13S,15S,16S,18S,20S,21S,23S,25S,26S,28S,30S,31S,33S,35S,36S,38S,40S,41R,42R,43R,44R,45R,46R,47R,48R,49R,50R,51R,52R,53R,54R,55R,56 ;R)-41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56-Hexadecahydroxy-2,4,7,9,12,14,17,19,22,24,27,29,32,34,37,39-hexadecaoxanonacyclo[36.2.2.2.2.2.2.2.2.2]h exapentacontane-5,10,15,20,25,30,35,40-octay
cyclooctakis-(1&;rarr;4)-[6-S-(2-carboxyethyl)-6-thio-α-D-glucopyranosyl]
unii-361lpm2t56
Sugammadex
UNII361LPM2T56
Description Sugammadex is a synthetic γ-cyclodextrin derivative, and acts as a reversal agent for neuromuscular block. Sugammadex shows nephroprotective effect in ischemia-reperfusion injury[1][2].
Related Catalog
In Vivo Sugammadex (100 mg/kg, IV, once) has a nephroprotective effect when given at the beginning of reperfusion after one hour of ischemic condition on rats[2].
References

[1]. de Boer HD, et al. Sugammadex, a new reversal agent for neuromuscular block induced by rocuronium in the anaesthetized Rhesus monkey. Br J Anaesth. 2006 Apr;96(4):473-9. Epub 2006 Feb 7.

[2]. Tercan M, Yılmaz İnal F, Seneldir H, Kocoglu H. Nephroprotective Efficacy of Sugammadex in Ischemia-Reperfusion Injury: An Experimental Study in a Rat Model. Cureus. 2021 Jun 17;13(6):e15726.

Density 1.6±0.1 g/cm3
Molecular Formula C72H104Na8O48S8
Molecular Weight 2002.151
Exact Mass 2000.408813
PSA 994.80000
LogP -1.25
Index of Refraction 1.610