105956-97-6
105956-97-6 structure
- Name: Clinafloxacin
- Chemical Name: 7-(3-Aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
- CAS Number: 105956-97-6
- Molecular Formula: C17H17ClFN3O3
- Molecular Weight: 365.78700
- Catalog: API Synthetic anti-infective drugs Quinolone
- Create Date: 2018-03-23 08:00:00
- Modify Date: 2024-01-02 10:41:47
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Clinafloxacin(PD-127391) is a fluoroquinolone antibiotic.Target: AntibacterialClinafloxacin is a broad-spectrum antibiotic of the quinolone carboxylic acid category currently in development for intravenous and oral therapy of serious infections [1]. Clinafloxacin is a novel fluoroquinolone with potent broad-spectrum in vitro activity against gram-positive, gram-negative, and anaerobic pathogens. Clinafloxacin is highly active against S. pneumoniae 7785 (MIC, 0.125 μg/mL), and neither gyrA nor parC quinolone resistance mutations alone have much effect on this activity [2]. Clinafloxacin is identified as the most active fluoroquinolone against S. pneumoniae when compared with ofloxacin, levofloxacin, sparfloxacin, grepafloxacin, and trovafloxacin and is currently being evaluated as an antipneumococcal agent [3].
| Name | 7-(3-Aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid |
|---|---|
| Synonyms |
MFCD00865120
Clinafloxacin 7-(3-aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid |
| Description | Clinafloxacin(PD-127391) is a fluoroquinolone antibiotic.Target: AntibacterialClinafloxacin is a broad-spectrum antibiotic of the quinolone carboxylic acid category currently in development for intravenous and oral therapy of serious infections [1]. Clinafloxacin is a novel fluoroquinolone with potent broad-spectrum in vitro activity against gram-positive, gram-negative, and anaerobic pathogens. Clinafloxacin is highly active against S. pneumoniae 7785 (MIC, 0.125 μg/mL), and neither gyrA nor parC quinolone resistance mutations alone have much effect on this activity [2]. Clinafloxacin is identified as the most active fluoroquinolone against S. pneumoniae when compared with ofloxacin, levofloxacin, sparfloxacin, grepafloxacin, and trovafloxacin and is currently being evaluated as an antipneumococcal agent [3]. |
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| Related Catalog | |
| References |
| Density | 1.573 g/cm3 |
|---|---|
| Boiling Point | 592.3ºC at 760 mmHg |
| Melting Point | 253-258ºC |
| Molecular Formula | C17H17ClFN3O3 |
| Molecular Weight | 365.78700 |
| Flash Point | 312ºC |
| Exact Mass | 365.09400 |
| PSA | 88.56000 |
| LogP | 3.12980 |
| Vapour Pressure | 7.14E-15mmHg at 25°C |
| Index of Refraction | 1.684 |
| Storage condition | 2-8°C |
| Symbol |
GHS08 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H361d |
| Precautionary Statements | P281 |
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| RTECS | VB1800600 |
| HS Code | 2933990090 |
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105956-97-6 |
| Literature: Journal of Medicinal Chemistry, , vol. 31, p. 983 - 991 |
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105956-97-6 |
| Literature: Journal of Medicinal Chemistry, , vol. 31, p. 983 - 991 |
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |