31255-10-4
31255-10-4 structure
- Name: Bromo-PEG2-bromide
- Chemical Name: 1,2-bis(2-bromoethoxy)ethane
- CAS Number: 31255-10-4
- Molecular Formula: C6H12Br2O2
- Molecular Weight: 275.96600
- Catalog: Signaling Pathways PROTAC PROTAC Linker
- Create Date: 2017-06-16 23:01:11
- Modify Date: 2024-01-11 19:06:08
-
Bromo-PEG2-bromide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
| Name | 1,2-bis(2-bromoethoxy)ethane |
|---|---|
| Synonyms |
AmbotzPEG1075
1,8-dibromo-3,6-dioxaoctane triethylene glycol dibromide 1,8-dibromo-4,7-dioxaoctane |
| Description | Bromo-PEG2-bromide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
PEGs |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Density | 1.655 g/cm3 |
|---|---|
| Boiling Point | 285.1ºC at 760 mmHg |
| Molecular Formula | C6H12Br2O2 |
| Molecular Weight | 275.96600 |
| Flash Point | 113.8ºC |
| Exact Mass | 273.92000 |
| PSA | 18.46000 |
| LogP | 1.80940 |
| Storage condition | 2-8°C |
|
~90%
31255-10-4 |
| Literature: Li, Yi; Dong, Jianming; Xun, Zhiqing; Zeng, Yi; Yu, Tianjun; Han, Yongbin; Chen, Jinping; Li, Ying-Ying; Yang, Guoqiang Chemistry - A European Journal, 2013 , vol. 19, # 24 p. 7931 - 7936 |
|
~58%
31255-10-4 |
| Literature: Farina, Paolo; Latter, Thomas; Levason, William; Reid, Gillian Dalton Transactions, 2013 , vol. 42, # 13 p. 4714 - 4724 |
|
~77%
31255-10-4 |
| Literature: Holmes, Brian T.; Snow, Arthur W. Patent: US2009/187037 A1, 2009 ; Location in patent: Page/Page column 2-3 ; |
|
~%
31255-10-4 |
| Literature: Rabouin, Daniel; Perron, Valerie; N'Zemba, Blaise; C.-Gaudreault, Rene; Berube, Gervais Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 3 p. 557 - 560 Title/Abstract Full Text View citing articles Show Details Berube, Gervais; Rabouin, Daniel; Perron, Valerie; N'Zemba, Blaise; Gaudreault, Rene-C.; Parent, Sophie; Asselin, Eric Steroids, 2006 , vol. 71, # 10 p. 911 - 921 |
|
~%
31255-10-4 |
| Literature: Mamedov,S.; Agaev,A.S. J. Gen. Chem. USSR (Engl. Transl.), 1963 , vol. 33, # 10 p. 3166 - 3171,3093 - 3098 |
|
~%
31255-10-4 |
| Literature: Movsumzade,M.M. et al. Journal of Organic Chemistry USSR (English Translation), 1972 , vol. 8, p. 2077 - 2079 Zhurnal Organicheskoi Khimii, 1972 , vol. 8, # 10 p. 2031 - 2034 |
|
~%
31255-10-4 |
| Literature: Nesmejanow et al. Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1951 , p. 708,709 Chem.Abstr., 1952 , p. 7514 |
|
~%
31255-10-4 |
| Literature: Delaney, Paul A.; Johnstone, Robert A. W.; Entwistle, Ian D. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1986 , p. 1855 - 1860 |
![1H-Isoindole-1,3(2H)-dione,2,2'-[1,2-ethanediylbis(oxy-2,1-ethanediyl)]bis- (9CI) structure](https://image.chemsrc.com/caspic/481/31255-11-5.png)
![N-butyl-N-[2-[2-[2-(dibutylamino)ethoxy]ethoxy]ethyl]butan-1-amine structure](https://image.chemsrc.com/caspic/080/114302-92-0.png)
![6-[[2-[2-[2-[(6-oxocyclohexa-2,4-dien-1-ylidene)methylamino]ethoxy]ethoxy]ethylamino]methylidene]cyclohexa-2,4-dien-1-one structure](https://image.chemsrc.com/caspic/419/112744-28-2.png)