Mipomersen
Modify Date: 2024-01-14 14:30:25
Mipomersen structure
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Common Name | Mipomersen | ||
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| CAS Number | 1000120-98-8 | Molecular Weight | 7177.00 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C230H305N67O122P19S19 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MipomersenMipomersen (ISIS 301012 free base) is an antisense oligonucleotide inhibitor of apolipoprotein B (apoB). Mipomersen has anti-HCV effect and reduces the infectivity of the HCV. Mipomersen can be used for the research of homozygous familial hypercholesterolemia (HoFH)[1][2]. |
| Name | mipomersen |
|---|---|
| Synonym | More Synonyms |
| Description | Mipomersen (ISIS 301012 free base) is an antisense oligonucleotide inhibitor of apolipoprotein B (apoB). Mipomersen has anti-HCV effect and reduces the infectivity of the HCV. Mipomersen can be used for the research of homozygous familial hypercholesterolemia (HoFH)[1][2]. |
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| Related Catalog | |
| In Vitro | Mipomersen (800 和 1000 μg/mL；72 小时) 可降低 HCVcc (JFH1) 感染的 Huh7/CD81 WT细胞中 80%-85% 的胞内 HCV RNA[2]。 |
| In Vivo | Mipomersen (25 mg/kg；腹腔注射，每周 2 次，共 11 周) 影响 h-apoB，h-apoB-100，Lp(a) 和 OxPL/h-apoB 的水平[1]。 Animal Model: Transgenic mice overexpressing human apolipoprotein B-100 (h-apoB mice) or h-apoB-100 plus human apo(a) (Lp(a) mice)[1] Dosage: 25 mg/kg Administration: Intraperitoneal injection; 25 mg/kg, twice weekly for 11 weeks Result: Time-dependently reduced the level of h-apoB-100 in Lp(a) mice and h-apoB in h-apoB mice. |
| References |
| Molecular Formula | C230H305N67O122P19S19 |
|---|---|
| Molecular Weight | 7177.00 |
| MIPOMERSEN |