Pemirolast potassium structure
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Common Name | Pemirolast potassium | ||
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CAS Number | 100299-08-9 | Molecular Weight | 266.301 | |
Density | N/A | Boiling Point | 454.8ºC at 760mmHg | |
Molecular Formula | C10H7KN6O | Melting Point | 310-311ºC (dec.) | |
MSDS | Chinese USA | Flash Point | 228.9ºC | |
Symbol |
GHS07 |
Signal Word | Warning |
Use of Pemirolast potassiumPemirolast Potassium (BMY 26517) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent.Target: Histamine H1 ReceptorPemirolast potassium (BMY 26517) is a new oral, nonbronchodilator antiallergy medication that is being evaluated for the therapy of asthma [1]. Pemirolast potassium (BMY 26517) inhibits chemical mediator release from tissue mast cells and is also shown to inhibit the release of peptides including substance P, Pemirolast potassium (BMY 26517) reduces kaolin intake by inhibition of substance P release in rats [2]. Pemirolast potently attenuates paclitaxel hypersensitivity reactions through inhibition of the release of sensory neuropeptides in rats [3]. Pemirolast potassium is used for the treatment of allergic conjunctivitis and prophylaxis for pulmonary hypersensitivity reactions to drugs such as paclitaxel [4]. |
Name | Pemirolast Potassium Hydrate |
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Synonym | More Synonyms |
Description | Pemirolast Potassium (BMY 26517) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent.Target: Histamine H1 ReceptorPemirolast potassium (BMY 26517) is a new oral, nonbronchodilator antiallergy medication that is being evaluated for the therapy of asthma [1]. Pemirolast potassium (BMY 26517) inhibits chemical mediator release from tissue mast cells and is also shown to inhibit the release of peptides including substance P, Pemirolast potassium (BMY 26517) reduces kaolin intake by inhibition of substance P release in rats [2]. Pemirolast potently attenuates paclitaxel hypersensitivity reactions through inhibition of the release of sensory neuropeptides in rats [3]. Pemirolast potassium is used for the treatment of allergic conjunctivitis and prophylaxis for pulmonary hypersensitivity reactions to drugs such as paclitaxel [4]. |
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Related Catalog | |
References |
Boiling Point | 454.8ºC at 760mmHg |
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Melting Point | 310-311ºC (dec.) |
Molecular Formula | C10H7KN6O |
Molecular Weight | 266.301 |
Flash Point | 228.9ºC |
Exact Mass | 266.031830 |
PSA | 77.97000 |
Vapour Pressure | 1.85E-08mmHg at 25°C |
Storage condition | -20°C Freezer, Under Inert Atmosphere |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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~10% Pemirolast potassium CAS#:100299-08-9 |
Literature: Sano, Atsunori; Ishihara, Masami Heterocycles, 1998 , vol. 48, # 4 p. 775 - 778 |
~% Pemirolast potassium CAS#:100299-08-9 |
Literature: Heterocycles, , vol. 48, # 4 p. 775 - 778 |
Precursor 2 | |
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DownStream 0 |
A combined analysis of two studies assessing the ocular comfort of antiallergy ophthalmic agents.
Clin. Ther. 25(4) , 1096-106, (2003) Many topical agents with similar efficacies are available for the treatment of ocular allergies. In addition to efficacy, comfort is an important criterion because it affects overall patient satisfact... |
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Comparison of 0.1% bromfenac sodium and 0.1% pemirolast potassium for the treatment of allergic conjunctivitis.
Jpn. J. Ophthalmol. 48(6) , 587-90, (2004) We compared the efficacy of a new nonsteroidal antiinflammatory drug (NSAID) eye drop, 0.1% bromfenac sodium (Bromfenac), with that of an antiallergic agent, 0.1% pemirolast potassium (Pemirolast), in... |
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Peripheral interstitial keratitis: a novel manifestation of ocular mastocytosis.
Cornea 25(3) , 364-7, (2006) To report a case of peripheral interstitial keratitis in a patient with mastocytosis.Clinical case description and immunohistologic examination of biopsied ocular tissue.A 22-year-old woman with biops... |
9-Methyl-3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one Potassium Salt |
9-Methyl-3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one Potassium Salt Hydrate |
4H-pyrido[1,2-a]pyrimidin-4-one, 9-methyl-3-(1H-tetrazol-5-yl)-, potassium salt |
potassium,9-methyl-3-(1,2,3-triaza-4-azanidacyclopenta-2,5-dien-5-yl)pyrido[1,2-a]pyrimidin-4-one |
Potassium 5-(9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)tetrazol-1-ide |
PeMirolast PotassiuM Hydrate |
MFCD01690051 |
4H-Pyrido[1,2-a]pyrimidin-4-one, 9-methyl-3-(1H-tetrazol-5-yl)-, potassium salt (1:1) |
Pemirolast potassium |
Pemirolast (potassium) |