1,4-Chrysenequinone

Modify Date: 2024-01-08 22:24:26

1,4-Chrysenequinone Structure
1,4-Chrysenequinone structure
Common Name 1,4-Chrysenequinone
CAS Number 100900-16-1 Molecular Weight 258.271
Density 1.4±0.1 g/cm3 Boiling Point 499.5±45.0 °C at 760 mmHg
Molecular Formula C18H10O2 Melting Point 210-212ºC(lit.)
MSDS N/A Flash Point 184.7±25.7 °C

 Use of 1,4-Chrysenequinone


1,4-Chrysenequinone, a polycyclic aromatic quinone, acts as an activator of aryl hydrocarbon receptor (AhR).

 Names

Name 1,4-Chrysenequinone
Synonym More Synonyms

 1,4-Chrysenequinone Biological Activity

Description 1,4-Chrysenequinone, a polycyclic aromatic quinone, acts as an activator of aryl hydrocarbon receptor (AhR).
Related Catalog
Target

AhR[1]

In Vitro 1,4-Chrysenequinone shows significant AhR ligand activity, with ECTCDD25s (concentration equivalent with 25% of TCDD max) of 9.7 nM and 1.9 μM in yeast and mouse hepatoma cell systems, respectively[1].
Cell Assay Mouse hepatoma (H1L1.1c2) cells (1.5 × 105 cells/well) are cultured in 96-well culture plates, and samples (1,4-Chrysenequinone) dissolved in dimethyl sulfoxide are added to the medium to achieve a final solvent concentration of 1%. After the plates are incubated at 37°C in 5% CO2 for 24 h, the cell viability is confirmed under a microscope. Subsequently, the medium is removed, and the cells are lysed. Adding luciferin as the substrate, the luciferase activity is determined under a luminometer and reported as relative light units. The concentrations producing luciferase activity equal to 25% of the maximal response to TCDD are calculated and also referred to as the ECTCDD25. The ratios of the ECTCDD25 of B[a]P to the ECTCDD25 of each of the compounds are calculated and referred to as IEFs[1].
References

[1]. Misaki K, et al. Aryl hydrocarbon receptor ligand activity of polycyclic aromatic ketones and polycyclic aromatic quinones. Environ Toxicol Chem. 2007 Jul;26(7):1370-9.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 499.5±45.0 °C at 760 mmHg
Melting Point 210-212ºC(lit.)
Molecular Formula C18H10O2
Molecular Weight 258.271
Flash Point 184.7±25.7 °C
Exact Mass 258.068085
PSA 34.14000
LogP 4.25
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.761

 Safety Information

Hazard Codes Xn: Harmful;
Risk Phrases R20/21/22
Safety Phrases 36
WGK Germany 3
HS Code 2914399090

 Synthetic Route

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1,4-Chrysenequinone Structure

1,4-Chrysenequinone

CAS#:100900-16-1

Literature: Journal of the American Chemical Society, , vol. 71, p. 3062,3067

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1,4-Chrysenequinone Structure

1,4-Chrysenequinone

CAS#:100900-16-1

Literature: Chemische Berichte, , vol. 92, p. 932,937

 Customs

HS Code 2914399090
Summary 2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

 Synonyms

1,4-CHRYSENEQUINONE
Chrysene-1,4-dione
Chrysene-1,4-quinone
1,4-Chrysenedione
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