100900-16-1
100900-16-1 structure
- Name: 1,4-Chrysenequinone
- Chemical Name: 1,4-Chrysenequinone
- CAS Number: 100900-16-1
- Molecular Formula: C18H10O2
- Molecular Weight: 258.271
- Catalog: Chemical reagent Organic reagent Tricyclic compound
- Create Date: 2018-05-27 08:00:00
- Modify Date: 2024-01-08 22:24:26
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1,4-Chrysenequinone, a polycyclic aromatic quinone, acts as an activator of aryl hydrocarbon receptor (AhR).
| Name | 1,4-Chrysenequinone |
|---|---|
| Synonyms |
1,4-CHRYSENEQUINONE
Chrysene-1,4-dione Chrysene-1,4-quinone 1,4-Chrysenedione |
| Description | 1,4-Chrysenequinone, a polycyclic aromatic quinone, acts as an activator of aryl hydrocarbon receptor (AhR). |
|---|---|
| Related Catalog | |
| Target |
AhR[1] |
| In Vitro | 1,4-Chrysenequinone shows significant AhR ligand activity, with ECTCDD25s (concentration equivalent with 25% of TCDD max) of 9.7 nM and 1.9 μM in yeast and mouse hepatoma cell systems, respectively[1]. |
| Cell Assay | Mouse hepatoma (H1L1.1c2) cells (1.5 × 105 cells/well) are cultured in 96-well culture plates, and samples (1,4-Chrysenequinone) dissolved in dimethyl sulfoxide are added to the medium to achieve a final solvent concentration of 1%. After the plates are incubated at 37°C in 5% CO2 for 24 h, the cell viability is confirmed under a microscope. Subsequently, the medium is removed, and the cells are lysed. Adding luciferin as the substrate, the luciferase activity is determined under a luminometer and reported as relative light units. The concentrations producing luciferase activity equal to 25% of the maximal response to TCDD are calculated and also referred to as the ECTCDD25. The ratios of the ECTCDD25 of B[a]P to the ECTCDD25 of each of the compounds are calculated and referred to as IEFs[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 499.5±45.0 °C at 760 mmHg |
| Melting Point | 210-212ºC(lit.) |
| Molecular Formula | C18H10O2 |
| Molecular Weight | 258.271 |
| Flash Point | 184.7±25.7 °C |
| Exact Mass | 258.068085 |
| PSA | 34.14000 |
| LogP | 4.25 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.761 |
| Hazard Codes | Xn: Harmful; |
|---|---|
| Risk Phrases | R20/21/22 |
| Safety Phrases | 36 |
| WGK Germany | 3 |
| HS Code | 2914399090 |
|
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100900-16-1 |
| Literature: Journal of the American Chemical Society, , vol. 71, p. 3062,3067 |
|
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100900-16-1 |
| Literature: Chemische Berichte, , vol. 92, p. 932,937 |
| Precursor 3 | |
|---|---|
| DownStream 1 | |
| HS Code | 2914399090 |
|---|---|
| Summary | 2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0% |