IRAK inhibitor 3

Modify Date: 2024-04-03 18:36:00

IRAK inhibitor 3 Structure
IRAK inhibitor 3 structure
Common Name IRAK inhibitor 3
CAS Number 1012343-93-9 Molecular Weight 439.48800
Density N/A Boiling Point N/A
Molecular Formula C21H21N5O4S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of IRAK inhibitor 3


IRAK inhibitor 3 is an interleukin-1 (IL-I) receptor-associated kinase (IRAK) kinase modulator extracted from patent WO2008030579 A2.

 Names

Name 4-[[[3-(3,4-dimethoxyphenyl)imidazo[1,2-b]pyridazin-6-yl]amino]methyl]benzenesulfonamide
Synonym More Synonyms

 IRAK inhibitor 3 Biological Activity

Description IRAK inhibitor 3 is an interleukin-1 (IL-I) receptor-associated kinase (IRAK) kinase modulator extracted from patent WO2008030579 A2.
Related Catalog
Target

IRAK[1]

In Vitro IRAK inhibitor 3 is an IRAK modulator, which can be used for treating an inflammatory condition, cell proliferative disorder, immune disorder[1].
Kinase Assay 5 μL of a solution of IRAK inhibitor 3 at a concentration of 50 μM or less in 1% (v/v) DMSO is added to the wells of a 96-well area Black Polystyrene plates. The final concentrations in the reaction well are 10 μM ATP, 0.5 μM IRAK4 CH373, 1.6 μM IRAKI peptide, 1 mM MgCl2, 2 mM DTT, 5 mM MnCl2, 0.01 % BSA, and 0.01 % Tween-20. The volume of the reaction is 45 μL. The reaction mixture is incubated at room temperature for 30 minutes and stopped with the addition of 5 μL of 100 mM EDTA[1].
References

[1]. Thomas Durand-Reville, et al. Irak modulators for treating an inflammatory condition, cell proliferative disorder, immune disorder. WO 2008030579 A2.

 Chemical & Physical Properties

Molecular Formula C21H21N5O4S
Molecular Weight 439.48800
Exact Mass 439.13100
PSA 132.45000
LogP 3.87600
Storage condition 2-8℃

 Synonyms

IRAK inhibitor 3
4-((3-(3,4-dimethoxyphenyl)imidazo[1,2-b]pyridazin-6-ylamino)methyl)-benzenesulfonamide
CS-0605
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