Simvastatin Hydroxy Acid Sodium Salt
Modify Date: 2024-01-11 20:46:22
Simvastatin Hydroxy Acid Sodium Salt structure
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Common Name | Simvastatin Hydroxy Acid Sodium Salt | ||
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| CAS Number | 101314-97-0 | Molecular Weight | 458.563 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H39NaO6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Simvastatin Hydroxy Acid Sodium SaltSimvastatin sodium is a lactone prodrug, can be hydrolysed to active hydroxy-acid by non-specific carboxyesterases or non-enzymatic processes. Simvastatin sodium shows a inhibition of HMG-CoA reductase with a Ki value of 0.12 nM[1][2]. |
| Name | sodium,(3R,5S)-7-[(1R,2R,6S,8S)-8-(2,2-dimethylbutanoyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate |
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| Synonym | More Synonyms |
| Description | Simvastatin sodium is a lactone prodrug, can be hydrolysed to active hydroxy-acid by non-specific carboxyesterases or non-enzymatic processes. Simvastatin sodium shows a inhibition of HMG-CoA reductase with a Ki value of 0.12 nM[1][2]. |
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| Related Catalog | |
| In Vitro | Simvastatin sodium shows a inhibition of HMG-CoA reductase in human lymphoblasts and SV40 transformed MRCS fibroblasts[1]. Simvastatin sodium (100 μM) inhibits the Na+/H+ antiport activity leading to a fall of intracellular pH and to a reduced cell proliferation.And the inhibitory effect is prevented by mevalonate but not dolichol or squalene[1]. |
| In Vivo | Simvastatin sodium (oral administration; 8 mg/kg; 18 days) reduces plasma cholesterol levels 33%, simvastatin can be used in combination with ezetimibe to treat dyslipidemia[1]. |
| References |
| Molecular Formula | C25H39NaO6 |
|---|---|
| Molecular Weight | 458.563 |
| Exact Mass | 458.264435 |
| PSA | 106.89000 |
| LogP | 2.77100 |
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~80%
Simvastatin Hyd... CAS#:101314-97-0 |
| Literature: Griffin, John; Lanza, Guido; Yu, Jessen Patent: US2005/261354 A1, 2005 ; Location in patent: Page/Page column 53 ; US 20050261354 A1 |
| Precursor 1 | |
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| DownStream 0 | |
| Sodium (3R,5R)-7-{(1S,2S,6R,8S,8aR)-8-[(2,2-dimethylbutanoyl)oxy]-2,6-dimethyl-1,2,6,7,8,8a-hexahydro-1-naphthalenyl}-3,5-dihydroxyheptanoate |
| Simvastatin Hydroxy Acid Sodium Salt |
| simvastatin sodium |
| Si-Methyl-N,N'N''-triphenyl-silantriyltriamin |
| 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-, sodium salt, (βR,δR,1S,2S,6R,8S,8aR)- (1:1) |
| trianilino-methyl-silane |
| simvastatin sodium salt |
| Silanetriamine,1-methyl-N,N',N''-triphenyl |
| Methyl-tris-anilino-silan |
| simivastin sodium salt |
| Simvastatin EP Impurity A Sodium Salt |
| Simvastatin Impurity 1 |