BiP inducer X
BiP inducer X structure
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Common Name | BiP inducer X | ||
|---|---|---|---|---|
| CAS Number | 101714-41-4 | Molecular Weight | 209.22 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 517.1±45.0 °C at 760 mmHg | |
| Molecular Formula | C9H7NO3S | Melting Point | 127 °C | |
| MSDS | Chinese USA | Flash Point | 266.5±28.7 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of BiP inducer XBiP inducer X, a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78, is an effective ER (endoplasmic reticulum) stress inhibitor. BiP inducer X preferentially induces BiP with slight inductions of GRP94, calreticulin, and C/EBP homologous protein. BiP inducer X protects neurons from ER stress[1][2]. |
| Name | [2-(3,4-dihydroxyphenyl)-2-oxoethyl] thiocyanate |
|---|---|
| Synonym | More Synonyms |
| Description | BiP inducer X, a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78, is an effective ER (endoplasmic reticulum) stress inhibitor. BiP inducer X preferentially induces BiP with slight inductions of GRP94, calreticulin, and C/EBP homologous protein. BiP inducer X protects neurons from ER stress[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | BiP inducer X (5 μM; 0-12 hours; SK-N-SH cells) increase BiP protein[1]. The induction of BiP by BiP inducer X (BIX) is mediated by activation of ER stress response elements (ERSEs) through the ATF6 pathway[1]. BiP inducer X (5 μM; 12 hours; pretreatment with SK-N-SH cells) inhibits cell death induced by ER stress involving inhibited activation of caspases 3/7 and 4[1]. |
| In Vivo | BiP inducer X administration reduces the insults due to cerebral infarction[1]. A 20 μg portion of BiP inducer X administration reduces ER stress-induced apoptosis induced in the penumbra by MCA occlusion[1]. Animal Model: Male adult ddY mice weighing 24-34 g (Japan SLC)[1] Dosage: 20 μg (2 μl) Administration: Intracerebroventricularly Result: Significantly increased the level of BiP protein 24 h after administration, confirming that administration of BIX induces BiP protein in vivo. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 517.1±45.0 °C at 760 mmHg |
| Melting Point | 127 °C |
| Molecular Formula | C9H7NO3S |
| Molecular Weight | 209.22 |
| Flash Point | 266.5±28.7 °C |
| Exact Mass | 209.014664 |
| PSA | 106.62000 |
| LogP | 1.53 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.665 |
|
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BiP inducer X CAS#:101714-41-4 |
| Literature: Bariana et al. Journal of the Indian Chemical Society, 1955 , vol. 32, p. 427,428, 429 |
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BiP inducer X CAS#:101714-41-4 |
| Literature: Dzierzgowski Chemische Berichte, 1894 , vol. 27, p. 1982 |
| Precursor 2 | |
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| DownStream 0 | |
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In vivo efficacy of human recombinant factor IX produced by the human hepatoma cell line HuH-7.
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PAX6 Isoforms, along with Reprogramming Factors, Differentially Regulate the Induction of Cornea-specific Genes.
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| BIX |
| 1-(3,4-dihydroxyphenyl)-2-thiocyanate-ethanone |
| 2-(3,4-Dihydroxyphenyl)-2-oxoethyl thiocyanate |
| 1-(3,4-Dihydroxy-phenyl)-2-thiocyanato-aethanon |
| Thiocyanicacid,3,4-dihydroxyphenacyl ester (6CI) |
| 1-(3,4-dihydroxy-phenyl)-2-thiocyanato-ethanone |
| BiP inducer X |
| Thiocyanic acid, 2-(3,4-dihydroxyphenyl)-2-oxoethyl ester |
| Thiocyanic acid,2-(3,4-dihydroxyphenyl)-2-oxoethyl ester |
| Thiocyanic acid, 2-(3,4-dihydroxyphenyl)-2-oxoethyl ester (9CI) |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: BiP inducer X
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- DC Chemicals Limited
- China
- Product Name: BIX
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: BIX
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Thiocyanic acid, 2-(3,4-dihydroxyphenyl)-2-oxoethyl ester (9CI)
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Delivery: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
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