Apoptosis inducer 4
Modify Date: 2024-01-09 12:21:22
Apoptosis inducer 4 structure
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Common Name | Apoptosis inducer 4 | ||
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| CAS Number | 2408050-83-7 | Molecular Weight | 815.02 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C41H50O11S3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Apoptosis inducer 4Apoptosis inducer 4 (Compound 12b) is an apoptosis inducer with anticancer activities[1]. |
| Name | Apoptosis inducer 4 |
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| Description | Apoptosis inducer 4 (Compound 12b) is an apoptosis inducer with anticancer activities[1]. |
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| Related Catalog | |
| In Vitro | Apoptosis inducer 4 (Compound 12b) (0-50 µM, 72 h) shows antiproliferative activities against cancer cells without obvious cytotoxicity against normal cells[1]. Apoptosis inducer 4 (0-2 µM, 48 h) causes cell cycle arrest at S phase in K562 cells and G1 phase in HepG2 cells[1]. Apoptosis inducer 4 (0-4 µM, 24 and 48 h) induces pyknosis in K562 cells, and induces mitochondrial membrane potentials decline[1]. Apoptosis inducer 4 (0-2 µM, 72 h) induces apoptosis in K562 and HepG2 cells[1]. Cell Proliferation Assay[1] Cell Line: HepG2, MCF-7, HCT-116, B16, K562, L-02 and PBMC Concentration: 0-50 µM Incubation Time: 72 h Result: Showed antiproliferative activities with IC50 values of 2.57 ± 0.12, 16.15 ± 1.02, 5.81 ± 1.17, 12.94 ± 0.88, 0.95 ± 0.06, 17.59 ± 0.93 and >50 µM against HepG2, MCF-7, HCT-116, B16, K562, L-02 and PBMC cells, respectively. Cell Cycle Analysis[1] Cell Line: K562 and HepG2 cells Concentration: K562 and HepG2 cells Incubation Time: 48 h Result: Arrested K562 cell cycle at S phase and HepG2 cell at G1 phase. Apoptosis Analysis[1] Cell Line: K562 and HepG2 cells Concentration: K562 and HepG2 cells Incubation Time: 72 h Result: Apoptotic ratios of K562 and HepG2 cells obviously increased in a concentration-dependent manner. |
| References |
| Molecular Formula | C41H50O11S3 |
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| Molecular Weight | 815.02 |