3H-1,2,3-Triazolo[4,5-d]pyrimidin-7-amine,3-β-D-ribofuranosyl-

Modify Date: 2024-01-04 21:53:29

3H-1,2,3-Triazolo[4,5-d]pyrimidin-7-amine,3-β-D-ribofuranosyl- structure	Common Name	3H-1,2,3-Triazolo[4,5-d]pyrimidin-7-amine,3-β-D-ribofuranosyl-
	CAS Number	10299-44-2	Molecular Weight	268.22900
	Density	2.29 g/cm3	Boiling Point	702.6ºC at 760 mmHg
	Molecular Formula	C₉H₁₂N₆O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	378.7ºC

Use of 3H-1,2,3-Triazolo[4,5-d]pyrimidin-7-amine,3-β-D-ribofuranosyl-

8-Azaadenosine is a potent ADAR1 (adenosine deaminases acting on double-stranded RNA) inhibitor. 8-Azaadenosine reduces A-to-I editing activity in a leukemia cell line, restores let-7 and inhibits leukemia stem cells self-renewal in vitro.

Name	8-azaadenosine
Synonym	More Synonyms

Description	8-Azaadenosine is a potent ADAR1 (adenosine deaminases acting on double-stranded RNA) inhibitor. 8-Azaadenosine reduces A-to-I editing activity in a leukemia cell line, restores let-7 and inhibits leukemia stem cells self-renewal in vitro.
Related Catalog	Signaling Pathways >> Others >> Others

Density	2.29 g/cm3
Boiling Point	702.6ºC at 760 mmHg
Molecular Formula	C₉H₁₂N₆O₄
Molecular Weight	268.22900
Flash Point	378.7ºC
Exact Mass	268.09200
PSA	152.43000
Vapour Pressure	1.01E-20mmHg at 25°C
Index of Refraction	2

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XZ5718000

CHEMICAL NAME :: 3H-1,2,3-Triazolo(4,5-d)pyrimidin-7-amine, 3-beta-D-ribofuranosyl-

CAS REGISTRY NUMBER :: 10299-44-2

LAST UPDATED :: 199709

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H12-N6-O4

MOLECULAR WEIGHT :: 268.27

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 169 mg/kg/5D-I

TOXIC EFFECTS :: Endocrine - hypoglycemia Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Human Cells - not otherwise specified

DOSE/DURATION :: 10 umol/L

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 31,3207,1982

Hazard Codes	Xn
Risk Phrases	R20/21/22
Safety Phrases	26-36

Precursor 0
DownStream 1
CAS#:53458-40-5 3H-1,2,3-Triazo...

8-aza-adenosine

8-Aza-adenosin

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 3H-1,2,3-Triazolo[4,5-d]pyrimidin-7-amine,3-β-D-ribofuranosyl-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: ￥2300/5 mg

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3H-1,2,3-Triazolo[4,5-d]pyrimidin-7-amine,3-β-D-ribofuranosyl-

Use of 3H-1,2,3-Triazolo[4,5-d]pyrimidin-7-amine,3-β-D-ribofuranosyl-

Names

Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Precursor & DownStream

Synonyms