HS 38
Modify Date: 2024-01-21 18:00:22
HS 38 structure
|
Common Name | HS 38 | ||
|---|---|---|---|---|
| CAS Number | 1030203-81-6 | Molecular Weight | 349.795 | |
| Density | 1.7±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C14H12ClN5O2S | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of HS 38HS-38 is a potent and selective DAPK1 and DAPK3 (ZIPK) inhibitor with IC50 of 200 nM for DAPK1 and Kd of 280 nM for ZIPK, also inhibits Pim3 (IC50=200 nM), and displays no activity against Src or Abl, little activity against EGFR; decreases RLC20 phosphorylation in cells, and decreases contractile force generated in mouse aorta, rabbit ileum, and calyculin A stimulated arterial muscle by decreasing RLC20 and MYPT1 phosphorylation; also promotes relaxation in Ca(2+)-sensitized vessels. |
| Name | 2-{[1-(3-Chlorophenyl)-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl]sulfanyl}propanamide |
|---|---|
| Synonym | More Synonyms |
| Description | HS-38 is a potent and selective DAPK1 and DAPK3 (ZIPK) inhibitor with IC50 of 200 nM for DAPK1 and Kd of 280 nM for ZIPK, also inhibits Pim3 (IC50=200 nM), and displays no activity against Src or Abl, little activity against EGFR; decreases RLC20 phosphorylation in cells, and decreases contractile force generated in mouse aorta, rabbit ileum, and calyculin A stimulated arterial muscle by decreasing RLC20 and MYPT1 phosphorylation; also promotes relaxation in Ca(2+)-sensitized vessels. |
|---|---|
| References | References 1. Carlson DA, et al. ACS Chem Biol. 2013 Dec 20;8(12):2715-23. 2. MacDonald JA, et al. Mol Pharmacol. 2016 Jan;89(1):105-17. View Related Products by Target DAPK |
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Molecular Formula | C14H12ClN5O2S |
| Molecular Weight | 349.795 |
| Exact Mass | 349.040009 |
| LogP | 1.27 |
| Index of Refraction | 1.775 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
| 2-{[1-(3-Chlorophenyl)-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl]sulfanyl}propanamide |
| Propanamide, 2-[[1-(3-chlorophenyl)-4,5-dihydro-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl]thio]- |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: HS38
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Tom
- Email: sales@echemcloud.com
- DC Chemicals Limited
- China
- Product Name: HS-38
- Price: $204.0/100mg
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: HS-38
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
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