Kinetensin
Modify Date: 2024-01-02 12:36:52
Kinetensin structure
|
Common Name | Kinetensin | ||
|---|---|---|---|---|
| CAS Number | 103131-69-7 | Molecular Weight | 1172.38000 | |
| Density | 1.41 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C56H85N17O11 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of KinetensinKinetensin is a neurotensin-like peptide isolated from pepsin-treated human plasma. |
| Name | Kinetensin (human) |
|---|---|
| Synonym | More Synonyms |
| Description | Kinetensin is a neurotensin-like peptide isolated from pepsin-treated human plasma. |
|---|---|
| Related Catalog | |
| Target |
Neurotensin Receptor[1] |
| In Vitro | The peptide kinetensin isolated from pepsin-treated human plasma induces a dose-dependent release of histamine when exposed to rat peritoneal mast cells. The threshold concentration is around 1 μM, the ED50 is 10 μM, and the optimal concentration of between 100 to 1000 μM released 80% of the total histamine. Kinetensin is 10 to 100 times less potent than neurotensin and equipotent with the opioid peptide dynorphin. The histamine release is clearly temperature-dependent, with no release occurring at 0 or 45 °C and with an optimum around 37 °C. The histamine release is significantly reduced in the absence of extracellular calcium[2]. |
| In Vivo | Kinetensin also induces a dose-dependent increase in vascular permeability when injected intradermally into rats[2]. |
| Cell Assay | Rat peritoneal mast cells are incubated with kinetensin at 37°C for 10 min. The incubation is stopped by the addition of 1.8 mL of ice-cold buffered saline and cells are separated from supernatant by centrifugation. Histamine release is expressed as per cent of total mast cell histamine[2]. |
| Animal Admin | Rats[2] Anesthetized Sprague-Dawley rats are given 25I-albumin i.v. Samples are then injected intradermally in 5x2 spots on the back and comprised saline as a control or kinetensin in different doses in 100 μL saline. After 20 rain, skin biopsies of 7 mm diameter are cut out, weighed and transferred to a gamma-counter. Results are expressed as: (counts per min (cpm) in tissue per gram wet weight/cpm in plasma per mL plasma)[2]. |
| References |
| Density | 1.41 g/cm3 |
|---|---|
| Molecular Formula | C56H85N17O11 |
| Molecular Weight | 1172.38000 |
| Exact Mass | 1171.66000 |
| PSA | 460.04000 |
| LogP | 4.33470 |
| Index of Refraction | 1.661 |
| Storage condition | 2~8°C |
| nrp |
| h-ile-ala-arg-arg-his-pro-tyr-phe-leu-oh |
| ile-ala-arg-arg-his-pro-tyr-phe-leu |
| iarrhpyfl |
| kinetensin |
| neurotensin-related peptide |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: ILE-ALA-ARG-ARG-HIS-PRO-TYR-PHE-LEU
- Price: Click To Check
- Purity: 98.0%
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- GL Biochem (Shanghai) Ltd.
- China
- Product Name: Kinetensin
- Price: $Inquiry/1g
- Purity: 98.0%
- Delivery: Inquiry
- Contact: Jackie Yang
- Email: ymbetter@glbiochem.com
- Nanjing Peptide Biotech Ltd
- China
- Product Name: Kinetensin
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- Email: chenglong.fan@njpeptide.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: KINETENSIN
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Delivery: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
- Taiwan Oyi peptide Co. Ltd
- China
- Product Name: Kinetensin
- Price: $Inquiry/1mg $Inquiry/100kg
- Purity: 98.0%
- Delivery: 1 Day
- Contact: Vinnie
- Email: Jamie@api-made.com
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Price: ￥990/1 mg
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