Shanghai Nianxing Industrial Co., Ltd
China
Product Name: ILE-ALA-ARG-ARG-HIS-PRO-TYR-PHE-LEU
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Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

GL Biochem (Shanghai) Ltd.
China
Product Name: Kinetensin
Price: $Inquiry/1g
Purity: 98.0%
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Contact: Jackie Yang

Nanjing Peptide Biotech Ltd
China
Product Name: Kinetensin
Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
Purity: 98.0%
Stocking Period: 7 Day
Contact: jom

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: KINETENSIN
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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Contact: Ms Wang

Taiwan Oyi peptide Co. Ltd
China
Product Name: Kinetensin
Price: $Inquiry/1mg $Inquiry/100kg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Vinnie

103131-69-7

103131-69-7 structure

103131-69-7 structure

Name: Kinetensin
Chemical Name: Kinetensin (human)
CAS Number: 103131-69-7
Molecular Formula: C₅₆H₈₅N₁₇O₁₁
Molecular Weight: 1172.38000
Catalog: Peptides
Create Date: 2018-12-22 12:22:25
Modify Date: 2024-01-02 12:36:52
Kinetensin is a neurotensin-like peptide isolated from pepsin-treated human plasma.

Name	Kinetensin (human)
Synonyms	nrp h-ile-ala-arg-arg-his-pro-tyr-phe-leu-oh ile-ala-arg-arg-his-pro-tyr-phe-leu iarrhpyfl kinetensin neurotensin-related peptide

Description	Kinetensin is a neurotensin-like peptide isolated from pepsin-treated human plasma.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Neurotensin Receptor Peptides Research Areas >> Neurological Disease
Target	Neurotensin Receptor[1]
In Vitro	The peptide kinetensin isolated from pepsin-treated human plasma induces a dose-dependent release of histamine when exposed to rat peritoneal mast cells. The threshold concentration is around 1 μM, the ED50 is 10 μM, and the optimal concentration of between 100 to 1000 μM released 80% of the total histamine. Kinetensin is 10 to 100 times less potent than neurotensin and equipotent with the opioid peptide dynorphin. The histamine release is clearly temperature-dependent, with no release occurring at 0 or 45 °C and with an optimum around 37 °C. The histamine release is significantly reduced in the absence of extracellular calcium[2].
In Vivo	Kinetensin also induces a dose-dependent increase in vascular permeability when injected intradermally into rats[2].
Cell Assay	Rat peritoneal mast cells are incubated with kinetensin at 37°C for 10 min. The incubation is stopped by the addition of 1.8 mL of ice-cold buffered saline and cells are separated from supernatant by centrifugation. Histamine release is expressed as per cent of total mast cell histamine[2].
Animal Admin	Rats[2] Anesthetized Sprague-Dawley rats are given 25I-albumin i.v. Samples are then injected intradermally in 5x2 spots on the back and comprised saline as a control or kinetensin in different doses in 100 μL saline. After 20 rain, skin biopsies of 7 mm diameter are cut out, weighed and transferred to a gamma-counter. Results are expressed as: (counts per min (cpm) in tissue per gram wet weight/cpm in plasma per mL plasma)[2].
References	[1]. Mogard MH, et al. The amino acid sequence of kinetensin, a novel peptide isolated from pepsin-treated human plasma: homology with human serum albumin, neurotensin and angiotensin. Biochem Biophys Res Commun. 1986 May 14;136(3):983-8. [2]. Sydbom A, et al. Stimulation of histamine release by the peptide kinetensin. Agents Actions. 1989 Apr;27(1-2):68-71.

Density	1.41 g/cm3
Molecular Formula	C₅₆H₈₅N₁₇O₁₁
Molecular Weight	1172.38000
Exact Mass	1171.66000
PSA	460.04000
LogP	4.33470
Index of Refraction	1.661
Storage condition	2~8°C

Hazard Codes	F+
Safety Phrases	22-24/25
WGK Germany	3.0