ABT-046
Modify Date: 2024-01-14 11:10:19
ABT-046 structure
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Common Name | ABT-046 | ||
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| CAS Number | 1031336-60-3 | Molecular Weight | 350.41400 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H22N4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ABT-046ABT-046 is a potent, selective, and orally bioavailable Diacylglycerol acyltransferase 1 (DGAT-1 ) inhibitor (IC50= 8 nM).IC50 value: 8 nM [1]Target: DGAT-1Oral administration at doses ≥0.03 mg/kg significantly reduced postprandial triglycerides in mice following an oral lipid challenge. Further assessment in both acute and chronic safety pharmacology and toxicology studies demonstrated a clean profile up to high plasma levels, thus culminating in the nomination of 14 as clinical candidate ABT-046. |
| Name | 2-[4-[4-(7-aminopyrazolo[1,5-a]pyrimidin-6-yl)phenyl]cyclohexyl]acetic acid |
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| Synonym | More Synonyms |
| Description | ABT-046 is a potent, selective, and orally bioavailable Diacylglycerol acyltransferase 1 (DGAT-1 ) inhibitor (IC50= 8 nM).IC50 value: 8 nM [1]Target: DGAT-1Oral administration at doses ≥0.03 mg/kg significantly reduced postprandial triglycerides in mice following an oral lipid challenge. Further assessment in both acute and chronic safety pharmacology and toxicology studies demonstrated a clean profile up to high plasma levels, thus culminating in the nomination of 14 as clinical candidate ABT-046. |
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| Related Catalog | |
| References |
| Molecular Formula | C20H22N4O2 |
|---|---|
| Molecular Weight | 350.41400 |
| Exact Mass | 350.17400 |
| PSA | 93.51000 |
| LogP | 4.30820 |
| Storage condition | 2-8℃ |
![Cyclohexaneacetic acid, 4-[4-(chlorocarbonyl)phenyl]-, ethyl ester, trans- structure](https://image.chemsrc.com/caspic/406/1031336-68-1.png)
![Cyclohexaneacetic acid, 4-[4-(cyanomethyl)phenyl]-, ethyl ester, trans- structure](https://image.chemsrc.com/caspic/106/1031336-85-2.png)
| CS-1213 |
| ABT 046 |
| ABT-046||ABT 046|ABT046 |
| trans-{4-[4-(7-aminopyrazolo[1,5-a]pyrimidin-6-yl)phenyl]cyclohexyl}acetic acid |
| ABT-046 |