1031336-60-3
1031336-60-3 structure
- Name: ABT-046
- Chemical Name: 2-[4-[4-(7-aminopyrazolo[1,5-a]pyrimidin-6-yl)phenyl]cyclohexyl]acetic acid
- CAS Number: 1031336-60-3
- Molecular Formula: C20H22N4O2
- Molecular Weight: 350.41400
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Acyltransferase
- Create Date: 2016-10-11 17:38:32
- Modify Date: 2024-01-14 11:10:19
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ABT-046 is a potent, selective, and orally bioavailable Diacylglycerol acyltransferase 1 (DGAT-1 ) inhibitor (IC50= 8 nM).IC50 value: 8 nM [1]Target: DGAT-1Oral administration at doses ≥0.03 mg/kg significantly reduced postprandial triglycerides in mice following an oral lipid challenge. Further assessment in both acute and chronic safety pharmacology and toxicology studies demonstrated a clean profile up to high plasma levels, thus culminating in the nomination of 14 as clinical candidate ABT-046.
| Name | 2-[4-[4-(7-aminopyrazolo[1,5-a]pyrimidin-6-yl)phenyl]cyclohexyl]acetic acid |
|---|---|
| Synonyms |
CS-1213
ABT 046 ABT-046||ABT 046|ABT046 trans-{4-[4-(7-aminopyrazolo[1,5-a]pyrimidin-6-yl)phenyl]cyclohexyl}acetic acid ABT-046 |
| Description | ABT-046 is a potent, selective, and orally bioavailable Diacylglycerol acyltransferase 1 (DGAT-1 ) inhibitor (IC50= 8 nM).IC50 value: 8 nM [1]Target: DGAT-1Oral administration at doses ≥0.03 mg/kg significantly reduced postprandial triglycerides in mice following an oral lipid challenge. Further assessment in both acute and chronic safety pharmacology and toxicology studies demonstrated a clean profile up to high plasma levels, thus culminating in the nomination of 14 as clinical candidate ABT-046. |
|---|---|
| Related Catalog | |
| References |
| Molecular Formula | C20H22N4O2 |
|---|---|
| Molecular Weight | 350.41400 |
| Exact Mass | 350.17400 |
| PSA | 93.51000 |
| LogP | 4.30820 |
| Storage condition | 2-8℃ |
| Precursor 4 | |
|---|---|
| DownStream 0 | |