Nitisinone structure
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Common Name | Nitisinone | ||
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CAS Number | 104206-65-7 | Molecular Weight | 329.228 | |
Density | 1.5±0.1 g/cm3 | Boiling Point | 486.2±45.0 °C at 760 mmHg | |
Molecular Formula | C14H10F3NO5 | Melting Point | 129-131°C | |
MSDS | Chinese USA | Flash Point | 247.9±28.7 °C |
Use of NitisinoneNitisinone(SC0735) is an inhibitor of the enzyme 4-hydroxyphenylpyruvate dioxygenase.Target: 4-Hydroxyphenylpyruvate DioxygenaseNitisinone is a drug used to slow the effects of hereditary tyrosinemia type 1. Nitisinone reduced urinary HGA levels from an average of 4.0 +/- 1.8 (SD) g/day to 0.2 +/- 0.2 g/day ( P < .001). Low-dose nitisinone effectively reduced urinary HGA levels in patients with alkaptonuria. Future long-term clinical trials are planned to determine the benefits of nitisinone in preventing joint deterioration and providing pain relief, and its long-term side effects [1]. Nitisinone can prevent the development of liver disease and significantly reduce the risk of developing hepatocellular carcinoma; however, vigorous surveillance for the development of HCC needs to be continued lifelong [2]. |
Name | nitisinone |
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Synonym | More Synonyms |
Description | Nitisinone(SC0735) is an inhibitor of the enzyme 4-hydroxyphenylpyruvate dioxygenase.Target: 4-Hydroxyphenylpyruvate DioxygenaseNitisinone is a drug used to slow the effects of hereditary tyrosinemia type 1. Nitisinone reduced urinary HGA levels from an average of 4.0 +/- 1.8 (SD) g/day to 0.2 +/- 0.2 g/day ( P < .001). Low-dose nitisinone effectively reduced urinary HGA levels in patients with alkaptonuria. Future long-term clinical trials are planned to determine the benefits of nitisinone in preventing joint deterioration and providing pain relief, and its long-term side effects [1]. Nitisinone can prevent the development of liver disease and significantly reduce the risk of developing hepatocellular carcinoma; however, vigorous surveillance for the development of HCC needs to be continued lifelong [2]. |
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Related Catalog | |
References |
Density | 1.5±0.1 g/cm3 |
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Boiling Point | 486.2±45.0 °C at 760 mmHg |
Melting Point | 129-131°C |
Molecular Formula | C14H10F3NO5 |
Molecular Weight | 329.228 |
Flash Point | 247.9±28.7 °C |
Exact Mass | 329.051117 |
PSA | 97.03000 |
LogP | 1.37 |
Vapour Pressure | 0.0±1.2 mmHg at 25°C |
Index of Refraction | 1.535 |
Storage condition | 2-8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Hazard Codes | Xi |
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RIDADR | NONH for all modes of transport |
HS Code | 2914700090 |
HS Code | 2914700090 |
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Summary | HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0% |
Generation of healthy mice from gene-corrected disease-specific induced pluripotent stem cells.
PLoS Biol. 9(7) , e1001099, (2011) Using the murine model of tyrosinemia type 1 (fumarylacetoacetate hydrolase [FAH] deficiency; FAH⁻/⁻ mice) as a paradigm for orphan disorders, such as hereditary metabolic liver diseases, we evaluated... |
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Serum markers in alkaptonuria: simultaneous analysis of homogentisic acid, tyrosine and nitisinone by liquid chromatography tandem mass spectrometry.
Ann. Clin. Biochem. 52 , 597-605, (2015) Alkaptonuria is a rare debilitating autosomal recessive disorder of tyrosine metabolism, where deficiency of homogentisate 1,2-dioxygenase results in increased homogentisic acid. Homogentisic acid is ... |
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A misguided 'pill in the pocket' approach with flecainide leading to cardiac arrest.
BMJ Case Rep. 2012 , doi:10.1136/bcr-2012-006868, (2012)
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nitisinonum |
2-(2-Nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione |
2-[2-Nitro-4-(trifluoromethyl)benzoyl]-1,3-cyclohexanedione |
2-(2-nitro-4-(trifluoromethyl)benzoyl)cyclohexane-1,3-dione |
Orfadin |
Nitisinone [INN] |
nitisinona |
Orfadin (TN) |
1,3-Cyclohexanedione, 2-[2-nitro-4-(trifluoromethyl)benzoyl]- |
Nitisone |
2-(2-Nitro-4-trifluoromethylbenzoyl)cyclohexane-1,3-dione |
2-[2-nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione |
Nitisinone |