Manzamine A hydrochloride

Modify Date: 2024-01-11 10:34:45

Manzamine A hydrochloride structure	Common Name	Manzamine A hydrochloride
	CAS Number	104264-80-4	Molecular Weight	585.22
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₆H₄₅ClN₄O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Manzamine A hydrochloride

Manzamine A hydrochloride, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC50s of 10.2 and 1.5μM, respectively. Manzamine A hydrochloride targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A hydrochloride has antimalarial and anticancer activities. Manzamine A hydrochloride also shows potent activity against HSV-1[1][2][3][4].

Name	Manzamine A hydrochloride

Description	Manzamine A hydrochloride, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC50s of 10.2 and 1.5μM, respectively. Manzamine A hydrochloride targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A hydrochloride has antimalarial and anticancer activities. Manzamine A hydrochloride also shows potent activity against HSV-1[1][2][3][4].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> GSK-3 Research Areas >> Cancer Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Cell Cycle/DNA Damage >> CDK Research Areas >> Neurological Disease Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3 Signaling Pathways >> Membrane Transporter/Ion Channel >> Proton Pump
Target	GSK-3β:10.2 μM (IC50) CDK5:1.5 μM (IC50) HIV-1 vacuolar ATPases Malaria
In Vitro	Manzamine A increases acidity in pancreatic cancer cells and non-malignant Vero cells. manzamine A is a potential inhibitor of autophagy by preventing autophagosome turnover. Manzamine A (10 µM; 2 hours; AsPC-1 cells) clearly induced an accumulation of p62 confirming an inhibition of autophagosome turnover[2]. Manzamine A represents an important lead structure for the development of novel antimalarial chemotherapies[3].
References	[1]. Hamann M, et al. Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer's disease. J Nat Prod. 2007;70(9):1397-1405. [2]. Kallifatidis G, et al. The marine natural product manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells [published correction appears in Mar Drugs. 2014;12(4):2305-7]. Mar Drugs. 2013;11(9):3500-3516. Published 2013 Sep 17. [3]. Winkler JD, et al. Antimalarial activity of a new family of analogues of manzamine A. Org Lett. 2006;8(12):2591-2594. [4]. Palem JR, et al. Manzamine A as a novel inhibitor of herpes simplex virus type-1 replication in cultured corneal cells. Planta Med. 2011;77(1):46-51.

Molecular Formula	C₃₆H₄₅ClN₄O
Molecular Weight	585.22

Manzamine A hydrochloride

Use of Manzamine A hydrochloride

Names

Manzamine A hydrochloride Biological Activity

Chemical & Physical Properties