SPI-112
Modify Date: 2024-01-07 23:54:29
SPI-112 structure
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Common Name | SPI-112 | ||
|---|---|---|---|---|
| CAS Number | 1051387-90-6 | Molecular Weight | 468.45 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H17FN4O5S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SPI-112SPI-112 is a potent, selective and competitive SHP2 (PTPN11) inhibitor with IC50s of 1 μM, 18.3 μM and 14.5 μM for SHP2, protein tyrosine phosphatase (PTP) and PTP1B, respectively[1][2]. |
| Name | SPI 112 |
|---|
| Description | SPI-112 is a potent, selective and competitive SHP2 (PTPN11) inhibitor with IC50s of 1 μM, 18.3 μM and 14.5 μM for SHP2, protein tyrosine phosphatase (PTP) and PTP1B, respectively[1][2]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 1 μM (SHP2), 18.3 μM (PTP) and 14.5 μM (PTP1B)[2] |
| In Vitro | SPI-112 has a polar -NO2 or a negatively charged -COOH group and has no detectable cellular activity, suggesting that SPI-112 is not cell permeable[1]. In surface plasmon resonance (SPR) binding assay, SPI-112 displays a 1:1 stoichiometric binding kinetics to SHP2 with a kinetic constant KD of 1.30 µM. Enzyme kinetic data obtained with SPI-112 are best fitted with the competitive inhibition model (Ki of 0.8 µM), suggesting that SPI-112 interacts with the catalytic site of SHP2[1]. |
| References |
| Molecular Formula | C22H17FN4O5S |
|---|---|
| Molecular Weight | 468.45 |
| Storage condition | -20℃ |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: SPI-112
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: SPI 112
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- DC Chemicals Limited
- China
- Product Name: SPI 112
- Price: $750.0/100mg $1350.0/250mg $2700.0/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
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