KS370G
Modify Date: 2024-03-03 12:06:25
KS370G structure
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Common Name | KS370G | ||
|---|---|---|---|---|
| CAS Number | 105955-01-9 | Molecular Weight | 283.32 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H17NO3 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of KS370GKS370G is an orally active hypoglycemic and cardiovascular protective agent. KS370G improves left ventricular hypertrophy and function in pressure-overload mice heart. KS370G reduces renal obstructive nephropathy[1][2]. |
| Name | 3-(3,4-dihydroxyphenyl)-N-(2-phenylethyl)prop-2-enamide |
|---|---|
| Synonym | More Synonyms |
| Description | KS370G is an orally active hypoglycemic and cardiovascular protective agent. KS370G improves left ventricular hypertrophy and function in pressure-overload mice heart. KS370G reduces renal obstructive nephropathy[1][2]. |
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| Related Catalog | |
| In Vivo | KS370G (1 mg/kg; oral; once daily for 8 weeks) 通过降低压力过载小鼠心脏 ERK、AKT 和 GSK3β 的磷酸化，改善左心室功能，抑制心脏肥厚[1]。 KS370G (10 mg/kg; oral; once daily for 13 days) 通过减少小鼠炎症和氧化应激减轻单侧输尿管梗阻引起的肾纤维化[2]。 Animal Model: Pressure-overload ICR mice model[1] Dosage: 1 mg/kg Administration: Oral gavage, once daily for 8 weeks Result: Inhibited cardiac hypertrophy and improved cardiac function induced by pressure overload. Decreased the plasma levels of atrial natriuretic peptide and lactate dehydrogenase. Significantly reduced pressure overload-induced increase of α-SMA and phosphorylation of ERK, AKT and GSK3β. Reduced cardiac collagen accumulation. Animal Model: Male ICR mice, unilateral ureteral obstruction (UUO) model[2] Dosage: 10 mg/kg Administration: Oral, once daily for 13 days Result: Significantly attenuated collagen deposition in the obstructed kidney and inhibited UUO-induced renal fibrosis markers expression, including fibronectin, type I collagen, vimentin, and α-smooth muscle actin (α-SMA). Significantly lowered the expression of renalinflammatory chemokines/adhesion molecules and monocyte cells marker (MCP-1, VCAM-1, ICAM-1 and CD11b). Reduced renal malondialdehyde levels and reversed the expression of renal antioxidant enzymes (SOD and catalase) after UUO. Significantly inhibited UUOinduced elevated plasma AngII and TGF-β1 levels, TGF-β1 protein expression and Smad3 phosphorylation. |
| References |
| Molecular Formula | C17H17NO3 |
|---|---|
| Molecular Weight | 283.32 |
| Exact Mass | 283.12100 |
| PSA | 73.05000 |
| LogP | 3.31020 |
| RIDADR | NONH for all modes of transport |
|---|
| N-caffeoyl-2-phenylethylamine |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: KS370G
- Price: Negotiable
- Purity: 99.51%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: KS370G
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- DC Chemicals Limited
- China
- Product Name: KS370G
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: 2-Propenamide, 3-(3,4-dihydroxyphenyl)-N-(2-phenylethyl)-
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Delivery: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
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