β-Interleukin I (163-171), human

Modify Date: 2024-01-03 15:51:57

β-Interleukin I (163-171), human Structure
β-Interleukin I (163-171), human structure
Common Name β-Interleukin I (163-171), human
CAS Number 106021-96-9 Molecular Weight 1004.99000
Density 1.419g/cm3 Boiling Point 1682.6ºC at 760mmHg
Molecular Formula C39H64N12O19 Melting Point N/A
MSDS N/A Flash Point 971.4ºC

 Use of β-Interleukin I (163-171), human


β-Interleukin I (163-171), human, an immunostimulatory fragment of human IL-1β peptide, is a T cell activator. β-Interleukin I (163-171), human is not an IL-1R-binding domain of IL-1β. β-Interleukin I (163-171), human is a potent adjuvant that enhances the immune response in a variety of exptl. situations[1][3][4].

 Names

Name val-gln-gly-glu-glu-ser-asn-asp-lys
Synonym More Synonyms

 β-Interleukin I (163-171), human Biological Activity

Description β-Interleukin I (163-171), human, an immunostimulatory fragment of human IL-1β peptide, is a T cell activator. β-Interleukin I (163-171), human is not an IL-1R-binding domain of IL-1β. β-Interleukin I (163-171), human is a potent adjuvant that enhances the immune response in a variety of exptl. situations[1][3][4].
Related Catalog
In Vitro β-Interleukin I (163-171), human (12.5-400 μg/mL, 72 h) stimulates mouse thymocyte proliferation[6].
In Vivo β-Interleukin I (163-171), human (50 μg, daily, a poorly immunogenic fibrosarcoma (CE-2) of BALB/c mice model) induces a consistent but limited inhibition of tumor growth[2]. β-Interleukin I (163-171), human (1 μmole/kg, i.v.) together with the T-dependent antigen SRBC increases the primary immune response against the antigen[3].
References

[1]. Nencioni L, et al. In vivo immunostimulating activity of the 163-171 peptide of human IL-1 beta. J Immunol. 1987 Aug 1;139(3):800-4.  

[2]. Forni G, et al. Ability of a nonapeptide of the human IL-1 beta to recruit anti-tumor reactivity in recipient mice. J Immunol. 1989 Jan 15;142(2):712-8.  

[3]. Boraschi D, , et al. In vivo stimulation and restoration of the immune response by the noninflammatory fragment 163-171 of human interleukin 1 beta. J Exp Med. 1988 Aug 1;168(2):675-86.  

[4]. Tagliabue, A., et al. (1997). Interleukin 1 and Its Synthetic Peptide 163–171 as Vaccine Adjuvants. Vaccine Design pp 167-173.

[5]. Boraschi D, et al. Binding and internalization of the 163-171 fragment of human IL-1 beta. Cytokine. 1992 May;4(3):201-4.  

[6]. Bajpai K, et al. Immunomodulating activity of analogs of noninflammatory fragment 163-171 of human interleukin-1beta. Immunopharmacology. 1998 Jan;38(3):237-45.  

 Chemical & Physical Properties

Density 1.419g/cm3
Boiling Point 1682.6ºC at 760mmHg
Molecular Formula C39H64N12O19
Molecular Weight 1004.99000
Flash Point 971.4ºC
Exact Mass 1004.44000
PSA 540.45000
Vapour Pressure 0mmHg at 25°C
Index of Refraction 1.573
Storage condition -20°C

 Safety Information

WGK Germany 3

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 Synonyms

β-Interleukin I (163-171)
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