Tamsulosin

Modify Date: 2024-01-02 12:15:04

Tamsulosin Structure
Tamsulosin structure
Common Name Tamsulosin
CAS Number 106133-20-4 Molecular Weight 408.512
Density 1.2±0.1 g/cm3 Boiling Point 595.5±60.0 °C at 760 mmHg
Molecular Formula C20H28N2O5S Melting Point 226-228ºC
MSDS N/A Flash Point 313.9±32.9 °C

 Use of Tamsulosin


Tamsulosin is a selective α1 receptor antagonist.Target: α1 receptorTamsulosin is a selective α1 receptor antagonist that has preferential selectivity for the α1A receptor in the prostate versus the α1B receptor in the blood vessels. Tamsulosin-treated patients had a 0.30-fold lower risk of developing acute urinary retention compared with control patients. None of the International Continence Society male questionnaire domain scores showed significant changes between the groups [1]. tamsulosin can be recommended for treating men after catheterization for AUR, and can reduce the likelihood of the need for re-catheterization [2].

 Names

Name tamsulosin
Synonym More Synonyms

 Tamsulosin Biological Activity

Description Tamsulosin is a selective α1 receptor antagonist.Target: α1 receptorTamsulosin is a selective α1 receptor antagonist that has preferential selectivity for the α1A receptor in the prostate versus the α1B receptor in the blood vessels. Tamsulosin-treated patients had a 0.30-fold lower risk of developing acute urinary retention compared with control patients. None of the International Continence Society male questionnaire domain scores showed significant changes between the groups [1]. tamsulosin can be recommended for treating men after catheterization for AUR, and can reduce the likelihood of the need for re-catheterization [2].
Related Catalog
References

[1]. Jeong, I.G., et al., Impact of tamsulosin on urinary retention following early catheter removal after robot-assisted laparoscopic radical prostatectomy: a prospective randomized controlled trial. Int J Urol, 2014. 21(2): p. 164-8.

[2]. Lucas, M.G., T.P. Stephenson, and V. Nargund, Tamsulosin in the management of patients in acute urinary retention from benign prostatic hyperplasia. BJU Int, 2005. 95(3): p. 354-7.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 595.5±60.0 °C at 760 mmHg
Melting Point 226-228ºC
Molecular Formula C20H28N2O5S
Molecular Weight 408.512
Flash Point 313.9±32.9 °C
Exact Mass 408.171906
PSA 108.26000
LogP 2.24
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.553

 Safety Information

HS Code 2935009090

 Synthetic Route

 Customs

HS Code 2935009090
Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

 Synonyms

amsulosin
Flomax
Benzenesulfonamide, 5-[(2R)-2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxy-
Tamsulosinum
5-[(2R)-2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide
[14C]-Tamsulosin
(R)-5-[2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide
Tamsulosine
Tamsulosina
5-{(2R)-2-[(2-{[2-(ethyloxy)phenyl]oxy}ethyl)amino]propyl}-2-(methyloxy)benzenesulfonamide
Tamsulosin
Tamsolusin
MFCD00871531
Tamsulosina [INN-Spanish]
Tamsulosine [INN-French]
(R)-(-)-5-[2-(2-(2-ethoxyphenoxy)ethylamino)propyl]-2-methoxybenzenesulfonamide
5-[(2R)-2-{[2-(2-Ethoxyphenoxy)ethyl]amino}propyl]-2-methoxybenzenesulfonamide
Tamsulosinum [INN-Latin]
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