Palifosfamide tromethamine

Modify Date: 2024-01-30 11:22:19

Palifosfamide tromethamine Structure
Palifosfamide tromethamine structure
Common Name Palifosfamide tromethamine
CAS Number 1070409-31-2 Molecular Weight 342.15700
Density N/A Boiling Point N/A
Molecular Formula C8H22Cl2N3O5P Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Palifosfamide tromethamine


Palifosfamide (tromethamine) is a synthetic alkylating agent with potential antineoplastic activity. As the stabilized active metabolite of ifosfamide, palifosfamide (tromethamine) irreversibly alkylates and crosslinks DNA through GC base pairs. This leads to an inhibition of DNA replication and ultimately cell death. Compared to ifosfamide, palifosfamide (tromethamine) is less toxic.

 Names

Name 2-amino-2-(hydroxymethyl)propane-1,3-diol,bis(2-chloroethylamino)phosphinic acid
Synonym More Synonyms

 Palifosfamide tromethamine Biological Activity

Description Palifosfamide (tromethamine) is a synthetic alkylating agent with potential antineoplastic activity. As the stabilized active metabolite of ifosfamide, palifosfamide (tromethamine) irreversibly alkylates and crosslinks DNA through GC base pairs. This leads to an inhibition of DNA replication and ultimately cell death. Compared to ifosfamide, palifosfamide (tromethamine) is less toxic.
Related Catalog
References

[1]. Jones B, Komarnitsky P, Miller GT, Amedio J, Wallner BP. Anticancer activity of stabilized palifosfamide in vivo: schedule effects, oral bioavailability, and enhanced activity with docetaxel and doxorubicin. Anticancer Drugs. 2012;23(2):173-184.

 Chemical & Physical Properties

Molecular Formula C8H22Cl2N3O5P
Molecular Weight 342.15700
Exact Mass 341.06700
PSA 157.88000

 Synonyms

ZIO-201-T
UNII-0X5A3C04ID
Palifosfamide tromethamine