CD 1530

Modify Date: 2024-01-07 19:14:13

CD 1530 Structure
CD 1530 structure
Common Name CD 1530
CAS Number 107430-66-0 Molecular Weight 398.49400
Density 1.29g/cm3 Boiling Point 610.7ºC at 760 mmHg
Molecular Formula C27H26O3 Melting Point N/A
MSDS N/A Flash Point 337.2ºC

 Use of CD 1530


CD1530 is a selective RARγ agonist with an Kd of 150 nM[1]. CD1530 has been used in combination with bexarotene to inhibit oral carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide in a mouse model of human oral-cavity and esophageal squamous-cell carcinoma[2].

 Names

Name 4-[7-(1-adamantyl)-6-hydroxynaphthalen-2-yl]benzoic acid
Synonym More Synonyms

 CD 1530 Biological Activity

Description CD1530 is a selective RARγ agonist with an Kd of 150 nM[1]. CD1530 has been used in combination with bexarotene to inhibit oral carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide in a mouse model of human oral-cavity and esophageal squamous-cell carcinoma[2].
Related Catalog
Target

RARγ:150 nM (Kd)

References

[1]. Bernard BA, et al. Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor gamma. Biochem Biophys Res Commun. 1992 Jul 31;186(2):977-83.

[2]. Tang XH, et al. Combination of bexarotene and the retinoid CD1530 reduces murine oral-cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide. Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8907-12.

 Chemical & Physical Properties

Density 1.29g/cm3
Boiling Point 610.7ºC at 760 mmHg
Molecular Formula C27H26O3
Molecular Weight 398.49400
Flash Point 337.2ºC
Exact Mass 398.18800
PSA 57.53000
LogP 6.37840
Vapour Pressure 9.03E-16mmHg at 25°C
Index of Refraction 1.688

 Synonyms

cd 1530
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