MDL 11,939
MDL 11,939 structure
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Common Name | MDL 11,939 | ||
|---|---|---|---|---|
| CAS Number | 107703-78-6 | Molecular Weight | 295.41900 | |
| Density | 1.084g/cm3 | Boiling Point | 434.2ºC at 760mmHg | |
| Molecular Formula | C20H25NO | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 205.6ºC | |
| Symbol |
GHS09 |
Signal Word | Warning | |
Use of MDL 11,939Glemanserin (MDL11939) is a potent and selective antagonist for serotonin receptor 5-HT2A (Ki=2.89, 0.54 and 2.5 nM for rat 5-HT2A, rabbit 5-HT2A and human 5-HT2A, respectively)[1][2]. |
| Name | MDL 11,939,α-Phenyl-1-(2-phenylethyl)-4-piperidinemethanol |
|---|---|
| Synonym | More Synonyms |
| Description | Glemanserin (MDL11939) is a potent and selective antagonist for serotonin receptor 5-HT2A (Ki=2.89, 0.54 and 2.5 nM for rat 5-HT2A, rabbit 5-HT2A and human 5-HT2A, respectively)[1][2]. |
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| Related Catalog | |
| In Vivo | Glemanserin (MDL11939) suppresses Morphine-induced increase in locomotor activity, behavioral sensitization and withdrawal symptoms in male mice[1]. |
| References |
| Density | 1.084g/cm3 |
|---|---|
| Boiling Point | 434.2ºC at 760mmHg |
| Molecular Formula | C20H25NO |
| Molecular Weight | 295.41900 |
| Flash Point | 205.6ºC |
| Exact Mass | 295.19400 |
| PSA | 23.47000 |
| LogP | 3.61260 |
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Selective remodeling of rabbit frontal cortex: relationship between 5-HT2A receptor density and associative learning.
Psychopharmacology 172(4) , 435-42, (2004) Associative learning during classical trace eyeblink conditioning has been shown to be regulated by serotonin 5-HT(2A )receptors and to be critically dependent on the integrity of frontal cortex. Chro... |
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Effect of 5-HT2 receptor antagonists on a cranial nerve reflex in the rabbit: evidence for inverse agonism.
Psychopharmacology 141 , 162, (1999) This study examined the role of the serotonin 5-HT2 receptor in motor function by examining the effect of antagonists on the motor performance of a cranial nerve reflex, the nictitating membrane (NM) ... |
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Modification of the effects of 5-methoxy-N,N-dimethyltryptamine on exploratory behavior in rats by monoamine oxidase inhibitors.
Psychopharmacology 201(1) , 55-66, (2008) The hallucinogenic tea known as ayahuasca is made from a combination of psychoactive plants that contribute the active components N,N-dimethyltryptamine (DMT) and 5-methoxy-DMT (5-MeO-DMT), as well as... |
| laminaritriose |
| Glemanserin |