MDL 11,939结构式
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常用名 | MDL 11,939 | 英文名 | MDL 11,939 |
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CAS号 | 107703-78-6 | 分子量 | 295.41900 | |
密度 | 1.084g/cm3 | 沸点 | 434.2ºC at 760mmHg | |
分子式 | C20H25NO | 熔点 | N/A | |
MSDS | 中文版 美版 | 闪点 | 205.6ºC | |
符号 |
GHS09 |
信号词 | Warning |
MDL 11,939用途葛兰素(MDL11939)是5-HT2A血清素受体的有效和选择性拮抗剂(大鼠5-HT2A、兔5-HT2A和人5-HT2A的Ki分别为2.89、0.54和2.5 nM)[1][2]。 |
英文名 | MDL 11,939,α-Phenyl-1-(2-phenylethyl)-4-piperidinemethanol |
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英文别名 | 更多 |
描述 | 葛兰素(MDL11939)是5-HT2A血清素受体的有效和选择性拮抗剂(大鼠5-HT2A、兔5-HT2A和人5-HT2A的Ki分别为2.89、0.54和2.5 nM)[1][2]。 |
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相关类别 | |
体内研究 | 葛兰素(MDL11939)抑制吗啡诱导的雄性小鼠运动活性、行为敏化和戒断症状的增加[1]。 |
参考文献 |
密度 | 1.084g/cm3 |
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沸点 | 434.2ºC at 760mmHg |
分子式 | C20H25NO |
分子量 | 295.41900 |
闪点 | 205.6ºC |
精确质量 | 295.19400 |
PSA | 23.47000 |
LogP | 3.61260 |
Selective remodeling of rabbit frontal cortex: relationship between 5-HT2A receptor density and associative learning.
Psychopharmacology 172(4) , 435-42, (2004) Associative learning during classical trace eyeblink conditioning has been shown to be regulated by serotonin 5-HT(2A )receptors and to be critically dependent on the integrity of frontal cortex. Chro... |
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Effect of 5-HT2 receptor antagonists on a cranial nerve reflex in the rabbit: evidence for inverse agonism.
Psychopharmacology 141 , 162, (1999) This study examined the role of the serotonin 5-HT2 receptor in motor function by examining the effect of antagonists on the motor performance of a cranial nerve reflex, the nictitating membrane (NM) ... |
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Modification of the effects of 5-methoxy-N,N-dimethyltryptamine on exploratory behavior in rats by monoamine oxidase inhibitors.
Psychopharmacology 201(1) , 55-66, (2008) The hallucinogenic tea known as ayahuasca is made from a combination of psychoactive plants that contribute the active components N,N-dimethyltryptamine (DMT) and 5-methoxy-DMT (5-MeO-DMT), as well as... |
laminaritriose |
Glemanserin |