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MDL 11,939

更新时间:2024-01-14 13:33:22

MDL 11,939结构式
MDL 11,939结构式
品牌特惠专场
常用名 MDL 11,939 英文名 MDL 11,939
CAS号 107703-78-6 分子量 295.41900
密度 1.084g/cm3 沸点 434.2ºC at 760mmHg
分子式 C20H25NO 熔点 N/A
MSDS 中文版 美版 闪点 205.6ºC
符号 GHS09
GHS09
信号词 Warning

 MDL 11,939用途


葛兰素(MDL11939)是5-HT2A血清素受体的有效和选择性拮抗剂(大鼠5-HT2A、兔5-HT2A和人5-HT2A的Ki分别为2.89、0.54和2.5 nM)[1][2]。

 MDL 11,939名称

英文名 MDL 11,939,α-Phenyl-1-(2-phenylethyl)-4-piperidinemethanol
英文别名 更多

 MDL 11,939生物活性

描述 葛兰素(MDL11939)是5-HT2A血清素受体的有效和选择性拮抗剂(大鼠5-HT2A、兔5-HT2A和人5-HT2A的Ki分别为2.89、0.54和2.5 nM)[1][2]。
相关类别
体内研究 葛兰素(MDL11939)抑制吗啡诱导的雄性小鼠运动活性、行为敏化和戒断症状的增加[1]。
参考文献

[1]. Pehek EA, et al. Evidence for the preferential involvement of 5-HT2A serotonin receptors in stress- and drug-induced dopamine release in the rat medial prefrontal cortex. Neuropsychopharmacology. 2006;31(2):265-277.

 MDL 11,939物理化学性质

密度 1.084g/cm3
沸点 434.2ºC at 760mmHg
分子式 C20H25NO
分子量 295.41900
闪点 205.6ºC
精确质量 295.19400
PSA 23.47000
LogP 3.61260

 MDL 11,939安全信息

符号 GHS09
GHS09
信号词 Warning
危害声明 H400
警示性声明 P273
危险品运输编码 UN 3077 9 / PGIII

 MDL 11,939文献25

更多文献
Selective remodeling of rabbit frontal cortex: relationship between 5-HT2A receptor density and associative learning.

Psychopharmacology 172(4) , 435-42, (2004)

Associative learning during classical trace eyeblink conditioning has been shown to be regulated by serotonin 5-HT(2A )receptors and to be critically dependent on the integrity of frontal cortex. Chro...

Effect of 5-HT2 receptor antagonists on a cranial nerve reflex in the rabbit: evidence for inverse agonism.

Psychopharmacology 141 , 162, (1999)

This study examined the role of the serotonin 5-HT2 receptor in motor function by examining the effect of antagonists on the motor performance of a cranial nerve reflex, the nictitating membrane (NM) ...

Modification of the effects of 5-methoxy-N,N-dimethyltryptamine on exploratory behavior in rats by monoamine oxidase inhibitors.

Psychopharmacology 201(1) , 55-66, (2008)

The hallucinogenic tea known as ayahuasca is made from a combination of psychoactive plants that contribute the active components N,N-dimethyltryptamine (DMT) and 5-methoxy-DMT (5-MeO-DMT), as well as...

 MDL 11,939英文别名

laminaritriose
Glemanserin
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