Resorcine

Modify Date: 2024-01-03 00:12:28

Resorcine Structure
Resorcine structure
 Common Name Resorcine
CAS Number 108-46-3 Molecular Weight 110.111
Density 1.27 Boiling Point 281 ºC
Molecular Formula C6H6O2 Melting Point 109-111°C
MSDS Chinese USA Flash Point 127 ºC
Symbol GHS07 GHS08 GHS09
GHS07, GHS08, GHS09		 Signal Word Danger

 Use of Resorcine


Resorcinol is an antiseptic and a disinfectant, and a chemical intermediate for the production of many other pharmaceuticals，is used to treat acne, seborrheic dermatitis, eczema, psoriasis, and other skin disorders.

 Names

Name resorcinol
Synonym More Synonyms

 Resorcine Biological Activity

Description Resorcinol is an antiseptic and a disinfectant, and a chemical intermediate for the production of many other pharmaceuticals，is used to treat acne, seborrheic dermatitis, eczema, psoriasis, and other skin disorders.
Related Catalog

 Chemical & Physical Properties

Density 1.27
Boiling Point 281 ºC
Melting Point 109-111°C
Molecular Formula C6H6O2
Molecular Weight 110.111
Flash Point 127 ºC
Exact Mass 110.036781
PSA 40.46000
LogP 0.76
Vapour density 3.8 (vs air)
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.612
Storage condition 0-6°C
Water Solubility 140 g/100 mL

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VG9625000
CHEMICAL NAME :
Resorcinol
CAS REGISTRY NUMBER :
108-46-3
BEILSTEIN REFERENCE NO. :
0906905
LAST UPDATED :
199712
DATA ITEMS CITED :
57
MOLECULAR FORMULA :
C6-H6-O2
MOLECULAR WEIGHT :
110.12
WISWESSER LINE NOTATION :
QR CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
29 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
301 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
160 mg/m3/1H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Behavioral - excitement Behavioral - tetany Behavioral - coma
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
215 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
213 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
110 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Blood - methemoglobinemia-carboxyhemoglobin
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
3360 mg/kg
TOXIC EFFECTS :
Skin and Appendages - primary irritation (after topical exposure) Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Behavioral - excitement Behavioral - tetany Behavioral - coma
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Amphibian - frog
DOSE/DURATION :
270 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold Cardiac - other changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5400 mg/kg/17D-I
TOXIC EFFECTS :
Endocrine - changes in thymus weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8450 mg/kg/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight Endocrine - changes in adrenal weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
504 mg/kg/28D-C
TOXIC EFFECTS :
Endocrine - changes in adrenal weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3600 mg/kg/17D-I
TOXIC EFFECTS :
Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
27300 mg/kg/13W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4800 mg/kg/12W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - hamster Ovary
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 14,251,1981 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-STEL 90 mg/m3 (20 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 45 mg/m3 (10 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 15,155,1977 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 15,155,1977 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 47,75,1978 TOXICOLOGY REVIEW JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 5(3),167,1986 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 10 ppm (45 mg/m3);STEL 20 ppm (90 mg/m3) JAN 1993 OEL-BELGIUM:TWA 10 ppm (45 mg/m3);STEL 20 ppm (90 mg/m3) JAN 1993 OEL-DENMARK:TWA 10 ppm (45 mg/m3) JAN 1993 OEL-FINLAND:TWA 10 ppm (45 mg/m3);STEL 20 ppm (90 mg/m3) JAN 1993 OEL-FRANCE:TWA 10 ppm (45 mg/m3) JAN 1993 OEL-HUNGARY:TWA 45 mg/m3;STEL 90 mg/m3;Skin JAN 1993 OEL-THE NETHERLANDS:TWA 10 ppm (45 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 10 ppm (45 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 10 ppm (45 mg/m3);STEL 20 ppm (90 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO RESORCINAL-air:10H TWA 10 ppm;STEL 20 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 67220 No. of Facilities: 4488 (estimated) No. of Industries: 45 No. of Occupations: 42 No. of Employees: 40431 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 67220 No. of Facilities: 6842 (estimated) No. of Industries: 30 No. of Occupations: 43 No. of Employees: 100792 (estimated) No. of Female Employees: 56465 (estimated)

 Safety Information

Symbol GHS07 GHS08 GHS09
GHS07, GHS08, GHS09
Signal Word Danger
Hazard Statements H302-H315-H317-H319-H370-H410
Precautionary Statements P260-P273-P280-P308 + P311-P333 + P313-P337 + P313
Target Organs Blood, Central nervous system, Respiratory system
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xn:Harmful
Risk Phrases R22;R36/38;R50
Safety Phrases S26;S61
RIDADR UN 2876 6.1/PG 3
WGK Germany 2
RTECS VG9625000
Packaging Group III
Hazard Class 6.1
HS Code 2907210000

 Synthetic Route

 Customs

HS Code 2907210000
Summary 2907210000 resorcinol。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。Lowest tariff:5.5%。General tariff:30.0%

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 Synonyms

1,3-diethynylenebenzene
1,3-benzenediol
Benzene,1,3-diethynyl
1,3-hydroquinone
meta-dihydroxy benzene
Resorcine
m-diethynylbenzene
meta-diethynylbenzene
2,3-Pyridinedicarboxylic acid
1,3-Benzenediol,Resorcinolum
EINECS 203-585-2
1,3-Benzenediol,Resorcinol
1,3-diethynyl-benzene
MFCD00002269
Hymecromone impurity A
1,3-dihydroxybenzene
Phloroglucinol Impurity 2
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